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临床试验/NCT00226733
NCT00226733终止2 期

Training Intensity After Coronary Bypass Grafting

Norwegian University of Science and Technology1 个研究点 分布在 1 个国家目标入组 60 人开始时间: 2004年3月1日最近更新:
适应症
干预措施

试验速览

阶段
2 期
状态
终止
入组人数
60
试验地点
1
主要终点
Oxygen Consumption

研究概览

简要总结

The purpose of this study is to investigate the effect of high and moderate intensity exercise training after coronary bypass surgery. The subjects are randomised to training at either 60-70% or 85-95% of their maximal capacity daily for four weeks. Primary outcome measure is change in maximal aerobic capacity, measured as change in maximal oxygen consumption, after the training period. Secondary outcome measures are change in quality of life, heart rate variability, ultrasound measures of the heart and blood variables, including endothelian markers.

详细描述

The exercise part of cardiac rehabilitation today is often composed of low to moderate intensity training. Several studies have found interval training with high intensity to be more effective in improving physical capacity in healthy subjects and also in different patient populations. We therefore wish to compare high intensity interval training with moderate intensity training in patients operated with coronary bypass surgery. Maximal oxygen consumption is shown to be the best indicator of how many years you life, both in healthy persons and in cardiac patients.

The subjects in this study is attending a four week rehabilitation program at an residential institution in Norway. They are randomised to do either a moderate or a high intensity aerobic training session each day.

The hypothesis in advance, was that high intensity interval training lead to a greater improvement in maximal oxygen consumption than training with moderate intensity. We also hypothesised that there would be no difference between the two groups after 6 months, since then the patients had to administer their own exercise training.

研究设计

研究类型
Interventional
分配方式
Randomized
干预模型
Parallel
主要目的
Treatment
盲法
None

入排标准

性别
All
接受健康志愿者
否

入选标准

  • •Coronary Artery Grafting (4-12 weeks ago)

排除标准

  • •Not able to exercise on a treadmill
  • •Left ventricle ejection fraction < 30%
  • •hemodynamic significant valve deficit (> NYHA classification II)

研究组 & 干预措施

A

Experimental

Interval exercise training with high intensity

干预措施: Exercise training (Behavioral)

B

Active Comparator

Exercise training with moderate intensity

干预措施: Exercise training (Behavioral)

结局指标

主要结局

Oxygen Consumption

次要结局

  • Quality of life
  • Pulse
  • Blodverdier
  • Ekkokardiografiske parametre

研究者

研究点 (1)

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