Training Intensity After Coronary Bypass Grafting

Phase 2

Terminated

• Conditions: Coronary Artery Bypass
• Interventions: Behavioral: Exercise training

• Registration Number: NCT00226733
• Lead Sponsor: Norwegian University of Science and Technology

Brief Summary

The purpose of this study is to investigate the effect of high and moderate intensity exercise training after coronary bypass surgery. The subjects are randomised to training at either 60-70% or 85-95% of their maximal capacity daily for four weeks. Primary outcome measure is change in maximal aerobic capacity, measured as change in maximal oxygen consumption, after the training period. Secondary outcome measures are change in quality of life, heart rate variability, ultrasound measures of the heart and blood variables, including endothelian markers.

Detailed Description

The exercise part of cardiac rehabilitation today is often composed of low to moderate intensity training. Several studies have found interval training with high intensity to be more effective in improving physical capacity in healthy subjects and also in different patient populations. We therefore wish to compare high intensity interval training with moderate intensity training in patients operated with coronary bypass surgery. Maximal oxygen consumption is shown to be the best indicator of how many years you life, both in healthy persons and in cardiac patients.

The subjects in this study is attending a four week rehabilitation program at an residential institution in Norway. They are randomised to do either a moderate or a high intensity aerobic training session each day.

The hypothesis in advance, was that high intensity interval training lead to a greater improvement in maximal oxygen consumption than training with moderate intensity. We also hypothesised that there would be no difference between the two groups after 6 months, since then the patients had to administer their own exercise training.

Study Timeline

• Study Start: 2004-03
• Study First Submitted: 2005-09-12
• Study First Submitted QC: 2005-09-26
• Study First Posted: 2005-09-27
• Primary Completion: 2007-03
• Study Completion: 2007-03
• Status Verified: 2008-04
• Last Update Submitted: 2010-05-17
• Last Update Posted: 2010-05-18

Recruitment & Eligibility

• Status: TERMINATED
• Sex: All
• Target Recruitment: 60

Inclusion Criteria

• Coronary Artery Grafting (4-12 weeks ago)

Exclusion Criteria

• Not able to exercise on a treadmill
• Left ventricle ejection fraction < 30%
• hemodynamic significant valve deficit (> NYHA classification II)

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
A	Exercise training	Interval exercise training with high intensity
B	Exercise training	Exercise training with moderate intensity

Primary Outcome Measures

Name	Time	Method
Oxygen Consumption

Secondary Outcome Measures

Name	Time	Method
Quality of life
Pulse
Blodverdier
Ekkokardiografiske parametre

Trial Locations

Locations (1)

Norwegian University of Science and Technology; 🇳🇴 Trondheim, Norway