The Effects of High-intensity and Moderate-intensity Exercise on Polycystic Ovary Syndrome
- Conditions
- ExercisePolycystic Ovary SyndromeCerebrovascular Circulation
- Interventions
- Other: High-Intensity ExerciseOther: Moderate-Intensity Exercise
- Registration Number
- NCT05394935
- Lead Sponsor
- Cardiff Metropolitan University
- Brief Summary
This study will investigate the impact of high- and moderate-intensity exercise on the cardiometabolic and brain health of women with Polycystic Ovary syndrome (PCOS). The aim is to measure and compare normal, healthy women without PCOS, to those with the condition.
All participants will undergo a blood test. The investigators will then assess the participants cardiovascular fitness by means of a maximal exercise test and measure body composition through height, weight, and hip-to-waist ratio.
Participants will undergo an MRI, where the investigators will assess the participants brain structure and how the brain responds to a number of tests. The investigators will also conduct some tests that will assess the participants cognition, such as IQ, memory etc.
The investigators will measure the blood vessels leading to the brain and the blood flow through them to measure how much blood the brain receives when rested, using ultrasound.
The investigators will use a number of tests to look at brain function, measure the responses to these tests, and compare them between the normal, healthy women and those with PCOS. This will show if women with PCOS have a similar brain function when rested and when their brains are tested to those without the condition.
The investigators will use exercise as an intervention, where the aim will be to investigate whether women with PCOS respond similarly to those without the condition to both high-intensity and moderate-intensity exercise. The tests of brain function will be repeated following the exercise, and see if both normal, healthy women and those with PCOS have a similar response to the brain function tests.
All tests and measures will be compared between the PCOS group, and the healthy control group to establish any potential differences or similarities as a result of the condition.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- Female
- Target Recruitment
- 34
- Polycystic Ovary Syndrome as diagnosed by any recognised criteria.
- Inactive (less than 40 mins of structured exercise per week).
- Pregnant or breastfeeding.
- Congenital adrenal hyperplasia, Cushing's syndrome, thyroid disease, hyperprolactinaemia and androgen secreting tumours.
- Known history of cardiovascular disease.
- Contraindications to MRI (fitted with ferromagnetic devices).
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- CROSSOVER
- Arm && Interventions
Group Intervention Description Polycystic Ovary Syndrome Moderate-Intensity Exercise Women with PCOS Controls Moderate-Intensity Exercise Healthy, age and BMI matched controls Polycystic Ovary Syndrome High-Intensity Exercise Women with PCOS Controls High-Intensity Exercise Healthy, age and BMI matched controls
- Primary Outcome Measures
Name Time Method Cerebrovascular Reactivity to Carbon Dioxide (CO2) Less than 1 hour post-exercise 6% CO2 administered to measure reactivity of the cerebrovasculature as measured by extra-cranial ultrasonography.
Cerebral blood velocity in the middle (MCAv) and posterior cerebral arteries (PCAv) during exercise During moderate-intensity exercise (50 minutes) MCAv and PCAv will be assessed using transcranial Doppler and employed throughout both bouts of acute exercise.
Neurovascular coupling (NVC) Less than 1 hour post-exercise NVC will be assessed using a visual task (flashing checkerboard) measured via transcranial Doppler.
Dynamic cerebral autoregulation (dCA) Less than 1 hour post-exercise dCA will be assessed using a squat-stand method to induce forced oscillations in blood pressure and measured using finger plethysmography and transcranial Doppler.
- Secondary Outcome Measures
Name Time Method Cerebral structure Baseline MRI will be employed to assess grey and white matter structure.
Cardiorespiratory fitness (CRF) Baseline CRF will be assessed via peak oxygen uptake using a step protocol on a cycle ergometer. to achieve VO2peak.
Hormone profile Baseline Hormonal profile will be measured through blood sampling, including androstenedione, sex hormone binding globulin and testosterone. From these values, free androgen index (FAI) will be calculated.
Cerebral metabolic rate of oxygen consumption Baseline Functional MRI will be employed to assess cerebral metabolic rate of oxygen consumption.
Cognitive testing Baseline A comprehensive cognitive battery will be employed to test across multiple cognitive sub-domains (IQ, working memory, episodic memory, attention and executive function).
Cerebral blood flow Baseline Functional MRI will be employed to assess global and regional cerebral blood flow.
Cerebrovascular reactivity Baseline Functional MRI will be employed to assess cerebrovascular reactivity during a breath hold challenge.
Blood pressure during exercise During High-intensity interval exercise (HIIT) (24 minutes) and Moderate-intensity steady state (MISS) (50 minutes) exercise Finger plethysmography will be used to non-invasively monitor systolic and diastolic blood pressure throughout both acute bouts of exercise.
Metabolic profile Baseline Metabolic profile will be measured through blood sampling, including fasting glucose and fasting insulin. From these values, the homeostatic model assessment of insulin resistance (HOMA-IR) will be calculated.
Lipid profile Baseline Lipid profile will be measured through blood sampling, including total cholesterol, high-density lipoproteins, low-density lipoproteins and triglycerides.
Trial Locations
- Locations (1)
Cardiff Metropolitan University
🇬🇧Cardiff, United Kingdom