Deep brain stimulation (DBS) of the nucleus accumbens in treatment-refractory patients with obsessive-compulsive disorder (OCD)

Academic Medical Center (AMC) (The Netherlands)0 sites16 target enrollmentJune 7, 2006

Overview

No summary available.

Registry

who.int

Start Date

June 7, 2006

End Date

TBD

Last Updated

11 years ago

Study Type

Interventional

Sex

All

Sponsor

Academic Medical Center (AMC) (The Netherlands)

•1\. Primary diagnosis: OCD (300\.3\) according to Diagnostic and Statistical Manual of Mental Disorders \- Fourth Edition (DSM\-IV) criteria using the mini\-international neuropsychiatric interview (MINI) plus interview as a diagnostic instrument
•2\. Illness duration \>5 years
•3\. Yale\-Brown obsessive\-compulsive scale (Y\-BOCS) total \>27, measured twice at least two weeks apart
•4\. Disabling severity with substantial functional impairment according to the DSM\-IV criterion C and a global assessment of function (GAF) score of \<45
•5\. Age 18 \- 65 years
•6\. Written informed consent
•7\. Able to fully understand the consequences of the procedure (intelligence quotient \[IQ] \>80\)
•8\. Dutch speaking and able to answer all study questions
•9\. Capable to make his or her own choice without coercion
•10\. Treatment refractory is defined as no response or insufficient response (still fulfilling the inclusion criteria) following:

•Any of the following unstable physical conditions: Parkinson's disease, dementia, epilepsy, schizophrenia or history of psychosis, alcohol or substance abuse during last 6 months, current tic disorder, antisocial personality disorder, body dismorphic disorder, pregnancy, use of psychiatric medication other than stable use of one SSRI or clomipramine, one benzodiazepine, one atypical antipsychotic.