Effects of deep brain stimulation of the nucleus accumbens on the dopaminergic activity in patients with Gilles-de-la-Tourette-syndrome
- Conditions
- The participants under study are recruited from a sample of patients suffering from a severe form of the Gilles-de-la-Tourette-syndrome who are waiting to receive deep-brain stimulation of the ncl. accumbens as therapeutic treatment.
- Registration Number
- EUCTR2006-005567-26-DE
- Lead Sponsor
- niversity of Aachen
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Authorised-recruitment may be ongoing or finished
- Sex
- All
- Target Recruitment
- Not specified
1. only patients will be included who hav acceded to undergo deep brain stimulation for treatment of their Tourette-syndrome;
2. as a consequence of 1. patients will
-be over 18 years of age
-have a certain diagnosis of GTS
-have a severe, chronic and medically refractory form of GTS
Are the trial subjects under 18? no
Number of subjects for this age range:
F.1.2 Adults (18-64 years) yes
F.1.2.1 Number of subjects for this age range
F.1.3 Elderly (>=65 years) no
F.1.3.1 Number of subjects for this age range
1. existence of other physical or neurological indispositions that might interfere with the study parameters or provide a risk to the patient in the course of the study
2. pregnancy
3. propofol hypersensitivity
4. incapability of giving consent personally
Study & Design
- Study Type
- Interventional clinical trial of medicinal product
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Main Objective: Monitoring effects of deep brain stimulation of the ncl. accumbens on the dopamine transmission in patients with Gilles-de-la-tourette.;Secondary Objective: To study the correlation between dopamine transmission and symptome severity.;Primary end point(s): Dopamine transmission as quantified by [18F]Fallypride-PET
- Secondary Outcome Measures
Name Time Method