DRKS00012596Completed未知
Influence of deep brain stimulation in the pedunculopontine nuclei on therapy-resistant gait and balance disorders in patients with idiopathic and atypical parkinsonian syndromes
niversitätsklinik für Stereotaktische Neurochirurgie0 sites11 target enrollmentStarted: November 7, 2017Last updated:
Trial Snapshot
- Phase
- 未知
- Status
- Completed
- Sponsor
- Enrollment
- 11
Study Overview
Brief Summary
No summary available.
Study Design
- Study Type
- Interventional
- Allocation
- N/a: Single Arm Study
- Masking
- Open (masking not used)
Eligibility Criteria
- Ages
- 40 Years to 75 Years (—)
- Sex
- All
Inclusion Criteria
- •Diagnosis of a probable PSP (Parkinsonsyndrom, progressive disease after the age of 40, PSP and marked postural instability with falls after the first year of the disease)
- •- UPDRS- item 13> / = 2 (2 = occasional falls, less than once a day)
- •PSPRS- item 5> / = 2 (average frequency of falls when walking without support, 2 = 1-4 falls per month)
- •- UPDRS- item 30> / = 2 (posture stability, 2 = response to a sudden backward-Pulling on the shoulders, while the patient stands with open eyes and legs slightly apart. The patient is prepared for it: no compensatory movement, would fall if not caught by the examiner)
- •PSPRS- Item 27> / = 2 (postural stability, patient would fall if not caught by the examiner)
Exclusion Criteria
- •- Dementia (Mattis Dementia Rating Scale Score <130/144)
- •- pronounced cerebral atrophy or pronounced brain parenchyma damage
- •- coagulation disorders (eg oral anticoagulation therapy, hepatic dysfunction)
- •- Reduced immune defense (immunosuppressive therapy or immune disease)
- •- other internal concomitant disease with significantly increased risk of operation
- •- Malignant disease
- •- Known epilepsy
- •- severe psychiatric illness (psychosis, severe depression, severe personality disorder).
Investigators
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