Study on the effects of sodium and potassium on blood pressure, vascular function and renal function in untreated (pre)hypertensive subjects
Completed
- Conditions
- elevated blood pressurevascular funtion10057166nierfunctie (estimated glomerular filtration rate)
- Registration Number
- NL-OMON35685
- Lead Sponsor
- TI Food and Nutrition
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- Not specified
- Target Recruitment
- 40
Inclusion Criteria
Systolic Blood Pressure between 130-159
No use of cardiovascular medication
Age 40 years and over
Exclusion Criteria
Chronic diseases (as diabetes, cardiovascular diseases, renal impairment)
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method <p>The primary parameters is flow-mediated dilation (FMD). </p><br>
- Secondary Outcome Measures
Name Time Method <p>Secondary parameters involve: diastolic blood pressure (DBP), centrale blood<br /><br>pressure, 24-hour ambulatory blood pressure, augmentation index (Aix), pulse<br /><br>wave velocity (PWV), vasomotion, estimated glomerular filtration rate (eGFR)<br /><br>and plasma biomarkers of endothelial function and low-grade inflammation, as<br /><br>asymmetric dimethylarginine (ADMA), endothelin-1, nitric oxides (NOx), monocyte<br /><br>chemoattractant protein (MCP-1), soluble endothelin selection (sE-selectin),<br /><br>soluble-thrombomodulin (sTM), von Willebrand factor (vWF), the cell adhesion<br /><br>molecules sVCAM-1 and sICAM-1, C-reactive protein (CRP), serum amyloid A (SAA),<br /><br>interleukin 6 (IL-6), interleukin 8 (IL-8) and tumor necrosis factor-a (TNF-a)</p><br>