Prevalence of Sonographic Abnormalities of Joints and Entheses in Psoriasis Patients With or Without Musculoskeletal Complains

Completed

• Conditions: Psoriasis
• Interventions: Other: Ultrasound examination

• Registration Number: NCT04074070
• Lead Sponsor: Assistance Publique - Hôpitaux de Paris

Brief Summary

The objectives of this study are:

* to estimate the prevalence and severity of inflammatory (synovitis, tenosynovitis, enthesitis, dactylitis) and structural (erosions, osteophytes, enthesophytes, cortical irregularities ) ultrasound lesions in psoriasis patients with or without related musculoskeletal symptoms;

* to compare them to healthy subjects or patients suffering from rheumatoid arthritis and osteoarthritis.

Detailed Description

Not available

Study Timeline

• Study First Submitted: 2019-08-19
• Study First Submitted QC: 2019-08-28
• Study First Posted: 2019-08-29
• Study Start: 2020-02-18
• Primary Completion: 2020-09-30
• Study Completion: 2020-09-30
• Status Verified: 2023-03
• Last Update Submitted: 2023-03-14
• Last Update Posted: 2023-03-16

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 25

Inclusion Criteria

• Age ≥ 18 years;
• Psoriasis diagnosed by a dermatologist;
• Able to participate in the study;
• Informed consent signed.

Exclusion Criteria

• Chronic disease likely to cause musculoskeletal symptoms (connective tissue diseases, inflammatory bowel diseases, overload disorders, crystal related arthritis, septic arthritis...).

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
Psoriatic arthritis	Ultrasound examination	-
Healthy individuals	Ultrasound examination	-
Psoriasis with and without musculoskeletal complains	Ultrasound examination	psoriasis with and without musculoskeletal complains

Primary Outcome Measures

Name	Time	Method
synovitis	through study completion, an average of 1 year	Number and percentage, N (%) of patients with at least one synovitis.
enthesitis	through study completion, an average of 1 year	N (%) of patients with at least one ultrasound enthesitis.
joint erosion	through study completion, an average of 1 year	N (%) of patients with at least one joint erosion.
osteophyte/ cortical irregularity	through study completion, an average of 1 year	N (%) of patients with at least one osteophyte/ cortical irregularity.
enthesophyte	through study completion, an average of 1 year	N (%) of patients with at least one enthesophyte.

Trial Locations

Locations (1)

Rheumatology Department, Ambroise Paré Hospital; 🇫🇷 Boulogne-Billancourt, France