Sonographic Signs of Gouty Arthritis in a Cohort of Egyptian Patients: a Cross Sectional Multicenter Study

Completed

• Conditions: Sonographic Signs of Gouty Arthritis in Diagnosed and Suspected Patients
• Interventions: Diagnostic Test: Evaluation of sonographic signs of gouty arthritis

• Registration Number: NCT04734093
• Lead Sponsor: Sohag University

Brief Summary

The study is a cross sectional observational multicenter study. It is established in collaboration with the Egyptian college of rheumatology study group (ECRsg). It is conditioned that all the study participants had either mono- or oligo-arthritis with effusion of the knee or the first metatarsophalangeal (MTP) joint in patients with a known history of gout or at high risk. Patients with any known chronic arthritis, comprising rheumatoid arthritis, Sjogren's syndrome, systemic lupus erythematosus, scleroderma, neuropathic arthritis, seronegative spondyloarthropathy, will be excluded from the study. None of the participants had a history of intra-articular injection or aspiration in the scanned joints for 3 months prior to the inclusion in the study. The sonographers will be blinded for clinical data and the EULAR scanning protocol for the knee and 1st MTP will be considered \[2\]. Further, scanning of the double contour sign over the femur condyles anteriorly and posteriorly in sagittal planes will be assessed. All the sonographers in the study had an experience between 5 and 10 years in the field of musculoskeletal ultrasound.

Detailed Description

Not available

Study Timeline

• Study Start: 2020-11-15
• Study First Submitted: 2021-01-28
• Study First Submitted QC: 2021-01-28
• Study First Posted: 2021-02-02
• Primary Completion: 2021-04-16
• Study Completion: 2021-04-16
• Status Verified: 2021-05
• Last Update Submitted: 2021-05-02
• Last Update Posted: 2021-05-04

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 300

Inclusion Criteria

• mono- or oligo-arthritis with effusion of the knee or the first metatarsophalangeal
• patients with a known history of gout or at high risk

Exclusion Criteria

• Patients with any known chronic arthritis, comprising rheumatoid arthritis, Sjoegren's syndrome, systemic lupus erythematosus, scleroderma, neuropathic arthritis, seronegative spondyloarthropathy
• History of intra-articular injection in the last 3 months.

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
Minia university recruited patients	Evaluation of sonographic signs of gouty arthritis	-
Sohag university recruited patients	Evaluation of sonographic signs of gouty arthritis	-
Aswan university recruited patients	Evaluation of sonographic signs of gouty arthritis	-
Assuit university recruited patients	Evaluation of sonographic signs of gouty arthritis	-
Monofia university recruited patients	Evaluation of sonographic signs of gouty arthritis	-
Ain shams university recruited patients	Evaluation of sonographic signs of gouty arthritis	-
Kasr Elini recruited patients	Evaluation of sonographic signs of gouty arthritis	-
Tanta university recruited patients	Evaluation of sonographic signs of gouty arthritis	-

Primary Outcome Measures

Name	Time	Method
Sonographic signs of gouty arthritis in the knee or 1st MTP joint	at baseline	Erosions, effusion, echogenic foci, and tophus using OMERACT definitions of sonographic signs of gouty arthritis

Trial Locations

Locations (1)

Ahmed Elsaman; 🇪🇬 Sohag, سوهاج, Egypt