Musculoskeletal Ultrasound in Asymptomatic Hyperuricemia
- Conditions
- Hyperuricemia
- Interventions
- Other: Uric acid level
- Registration Number
- NCT02502565
- Lead Sponsor
- Washington D.C. Veterans Affairs Medical Center
- Brief Summary
An observational study to evaluate the prevalence of US changes of gout in the joints and tendons of patients with different degrees of asymptomatic hyperuricemia. The investigators' findings may support the extension of the spectrum of urate disease, and define a subset of patients that may benefit from early urate-lowering therapy.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- UNKNOWN
- Sex
- All
- Target Recruitment
- 150
Inclusion Criteria
- Patients must have at least one serum uric acid level l ≥ 7.0 mg/dL within the last two years without a clinical diagnosis of gout per American College of Rheumatology criteria30 (appendix A).
- Patients, of matched gender and age, with normal uric acid levels will serve as controls.
Exclusion Criteria
- Patients who meet or have met the ACR criteria for Gout, unable to read English, and/or have terminal illness will not be eligible to participate in the study.
- Patients with a diagnosis of skin psoriasis31, rheumatoid arthritis, or spondyloarthropathies will not be eligible to participate.
- Patients who are on urate-lowering therapy.
- Patients with 1 or 2 total knee replacements.
Study & Design
- Study Type
- OBSERVATIONAL
- Study Design
- Not specified
- Arm && Interventions
Group Intervention Description Uric Acid Level Uric acid level -
- Primary Outcome Measures
Name Time Method Number of Urate Depositions Detected in Ultrasound 2 years
- Secondary Outcome Measures
Name Time Method
Trial Locations
- Locations (2)
WashingtonVAMC
🇺🇸Washington, District of Columbia, United States
Howard University Hospital
🇺🇸Washington, District of Columbia, United States