Efficacy of omeprazole plus sucralfate suspension and omeprazole alone for prevent post-endoscopic variceal ligation ulcer in cirrhotic Child-Pugh A and B patients

Phase 3

Active, not recruiting

• Conditions: Patients age 18- 75 years old with Cirrhosis Child- Pugh A and B come to treatment esophageal varices by endoscopic variceal ligation.Post endoscopic variceal ligation ulcer is the out; Cirrhosis Child- Pugh A and B; Post- endoscopic variceal ligation ulcer

• Registration Number: TCTR20190421003
• Lead Sponsor: Srinagarind Hospital Khonkaen University

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Study Start: 2019-04-21
• Study Completion: 2019-05-01
• Last Update Posted: 19 August 2024

Recruitment & Eligibility

• Status: Active, not recruiting
• Sex: All
• Target Recruitment: 108

Inclusion Criteria

Patients age 18-75 years old in the Srinagarind Hospital between years 2019-2020 and receive a diagnosis of cirrhosis child-pugh A and B from any cause with presented esophageal varices by esophagogastroduodenoscopy.
•Patients accept for endoscopic variceal ligation for primary prophylaxis upper gastrointestinal bleeding.
•Voluntary to participate in the research

Exclusion Criteria

Patients with contraindications to endoscopic varices ligation under general anesthesia such as do not cooperate, patients with risk bleeding cannot be solved by providing blood components (INR> 1.5, platelet <80,000).
•Patients had history of endoscopic variceal ligation or sclerotherapy or surgery.
•Patients presents with ulcer or Barrett’s metaplasia at varices before endoscopic variceal ligation.
•Patients do not stop antiplatelet at least 10 days.
•Pregnancy or lactation.
•Organ transplant.
•Drug allergy (omeprazole or sucralfate or general anesthesia).

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Proportion ulcer patients 2 week EGD and evaluation ulcer (positive or negative)

Secondary Outcome Measures

Name	Time	Method
Adverse drug reaction 2 weel Present of nausia or vomitting, Dysphagia, GI bleed (Positive of negative)