Clinical investigation for the relation between dose amounts of antipsychotics and skin carbonylstress condition. - Antipsychotics and skin carbonyl stress.

We investigated the relationship among skin AGE levels, minimal response dose (MRD) with UVA for photosensitivity and the daily dose of antipsychotic agents in patients with schizophrenia and healthy controls. We enrolled 14 patients with schizophrenia and 14 healthy controls. Measurement of skin AGE levels was conducted with AGE scanner, a fluorometric method for assaying skin AGE levels. Measurement of MRD was conducted with UV irradiation device. Skin AGE levels and MRD at 24, 48 and 72 h in patients with schizophrenia showed a higher tendency for photosensitivity than in the controls, but the difference was statistically insignificant. Multiple linear regression analysis using skin AGE levels failed to show any influence of independent variables. MRD did not affect skin AGE levels. Photosensitivity to UVA in patients with schizophrenia recieving treatment with antipsychotic agents might not be affected by skin AGE levels.