Multiparametric Characterization of Orbital Tumors by MRI
- Conditions
- Orbital Tumors
- Interventions
- Other: MRI
- Registration Number
- NCT01884207
- Lead Sponsor
- Charite University, Berlin, Germany
- Brief Summary
Prospective study on patients with orbital tumors of unknown origin. Aim of the study is to differentiate benign from malignant tumors upon MR imaging. Magnetic resonance imaging of the orbit will be performed including standard morphological sequences and advanced sequence techniques. These advanced sequence techniques may allow to differentiate benign from malignant tumors based on their cellularity and vascularity (diffusion and perfusion imaging). These MRI data will be analysed and the level of diffusion and perfusion will be measured and compared to the histological findings. Cut-off values of diffusion and perfusion will be calculated that allow to separate benign from malignant tumors.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 65
- non-diagnosed orbital tumors
- any metal implants, non-MRI compatible
- age below 18
- pregnancy
- recent surgery
- recent severe medical diseases
Study & Design
- Study Type
- OBSERVATIONAL
- Study Design
- Not specified
- Arm && Interventions
Group Intervention Description orbital tumors MRI -
- Primary Outcome Measures
Name Time Method multiparametric characterization of orbital tumors by MRI 24 months The level of diffusion and perfusion (multiparametric characterization) of the orbital tumors will be measured and the outcome measure is the ability of diffusion and perfusion imaging to predict malignancy. These parameters will be compared to histopathology in terms of separating benign vs. malignant tumors.
- Secondary Outcome Measures
Name Time Method
Trial Locations
- Locations (1)
Charite University
🇩🇪Berlin, Germany