NL-OMON48755撤回不适用
The Use of Milrinone in Neonates with Persistent Pulmonary Hypertension of the Newborn: A Randomised Controlled Trial Pilot Study - MINT 1 Study
RCSI Clinical Research Centre, Royal College of Surgeons in Ireland0 个研究点目标入组 15 人开始时间: 待定最近更新:
适应症
试验速览
- 阶段
- 不适用
- 状态
- 撤回
- 发起方
- 入组人数
- 15
研究概览
简要总结
暂无简介。
研究设计
- 研究类型
- Interventional
入排标准
- 年龄范围
- 2 至 11（—）
入选标准
- •1) Gestational age *34 weeks and birth weight *2000 grams
- •2) * 10 postnatal days of life and within 4 days of admission
- •3) Echocardiographic diagnosis of PPHN
- •4) Absence of significant congenital heart defect excluding a small atrial
- •septal defect or ventricular septal defect (measuring< 3mm)
- •5) Oxygenation index of * 10
排除标准
- •1) Lethal congenital anomalies or obvious syndrome
- •2) Bleeding diathesis (abnormal coagulation screen/platelet <100,000/ mm3)
- •3) The presence of Intraventricular haemorrhage.
- •4) Diastolic Hypotension (defined as a diastolic blood pressure less than the
- •3rd centile for any given gestation) unresponsive to medical treatment (*30
- •mL/kg fluid bolus and * 2 inotropes of at least 10 *g/ kg/min)
- •5) Hypoxic-ischemic encephalopathy undergoing therapeutic hypothermia
- •6) Evidence of renal impairment (Creatinine > 100micromol/l)
- •7) Severe Hypovolaemia: Heart rate > 180, capillary refill > 5 seconds, urine
- •output < 0.5ml/kg/hour, in addition to diastolic hypotension mentioned above.
研究者
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