Validation study about halitosis-reducing effects by long-term usage of zinc chloride-containing toothpaste and copper gluconate-containing mouth-rinse solutio
- Conditions
- Healthy male adults
- Registration Number
- JPRN-UMIN000042257
- Lead Sponsor
- KSO Corporation
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Complete: follow-up complete
- Sex
- Male
- Target Recruitment
- 30
Not provided
(1) At the screening test, subjects who were determined as a patient having some dental caries (over C3 level) and/or severe periodontal disease. (2) Subjects with medical treatment for diabetic, chronic kidney, digestive, lung or cancer diseases. (3) Subjects having need of some kind of scaling with oral surgery treatment and/or anesthesia. (4) Subjects with some kind of allergy. (5) Subjects equipped with removable denture. (6) Subjects with smoking habit. (7) Subjects who are now under the other clinical trials with some kind of medicine/food, or going to take part in those trials. (8) Subjects who have took in some kind of antibiotic and/or antibacterial agent, regularly or within the last month to the screening test. (9) All through this trial, subjects who have any difficulty in refraining from using some kind of mouth-rinse solution and/or interdental brush. (10) Others who have been determined as ineligible for participation, judging from the principal/sub investigator's opinions.
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Concentrations of volatile sulfur compounds, such as H2S, Me3SH and Me2S
- Secondary Outcome Measures
Name Time Method 1. Gingivitis index 2. Swelling 3. Reddening 4. Overall effectiveness 5. Tongue coating