Some Characteristics of Interaction Between Heart and Kidneys in Cardio-Renal Syndrome Type 1 and Type 2
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Heart Failure
- Sponsor
- Tbilisi State University
- Enrollment
- 11
- Primary Endpoint
- renal impairment (defined as a Glomerular Filtration Rate less than 60 mL/min per 1.73 m2)
- Status
- Completed
- Last Updated
- 8 years ago
Overview
Brief Summary
The aim of the study is to explore association between increased central venous pressure, Ejection Fraction and renal dysfunction (eGFR) in patients with Cardio-Renal Syndromes type 1 and 2. The pilot study was set to provide the expected correlation coefficient for a sample size determination of the subsequent study.
Detailed Description
OBJECTIVES The aim of the study is to explore association between increased central venous pressure (CVP), Ejection Fraction (EF) and renal dysfunction (eGFR) in patients with Cardio-Renal Syndromes type 1 and 2. BACKGROUND The pathophysiology of impaired renal function in cardiovascular disease is multifactorial. Recent investigations suggest that management of patients based on low-flow theory does not lead to improved outcomes. Relative importance of right heart dysfunction (manifested as increased CVP) has not been evaluated . Precise understanding of bidirectional pathways by which the heart and kidneys influence each other is necessary to define optimal treatment strategies specific to the subtypes, as therapies directed towards one organ system may have beneficial or unfavorable effects on the other. METHODS The study is of non-experimental (observational) type, based on retrospective chart review. The patients' personal identifiers are concealed and an anonymized datasets used (unique code given to each patient, which is kept secure under the control of hospital staff).
Investigators
George Lobzhanidze
MD
Tbilisi State University
Eligibility Criteria
Inclusion Criteria
- •HF (NYHA class I - IV, with preserved and reduced EF) and reduced GFR (Cardio-Renal Syndromes 1 and 2)
Exclusion Criteria
- •Independent risk factors for renal impairment (e.g. diabetes, sepsis)
- •Primary nephropathy or secondary nephropathy due to diseases other than HF
Outcomes
Primary Outcomes
renal impairment (defined as a Glomerular Filtration Rate less than 60 mL/min per 1.73 m2)
Time Frame: through study completion, an average of 1 year
Estimated Glomerular Filtration Rate has been assessed with the Modification of Diet in Renal Disease formula