Some Characteristics of Interaction Between Heart and Kidneys in Cardio-Renal Syndrome Type 1 and Type 2
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 11
- 主要终点
- renal impairment (defined as a Glomerular Filtration Rate less than 60 mL/min per 1.73 m2)
研究概览
简要总结
The aim of the study is to explore association between increased central venous pressure, Ejection Fraction and renal dysfunction (eGFR) in patients with Cardio-Renal Syndromes type 1 and 2. The pilot study was set to provide the expected correlation coefficient for a sample size determination of the subsequent study.
详细描述
OBJECTIVES
The aim of the study is to explore association between increased central venous pressure (CVP), Ejection Fraction (EF) and renal dysfunction (eGFR) in patients with Cardio-Renal Syndromes type 1 and 2.
BACKGROUND
The pathophysiology of impaired renal function in cardiovascular disease is multifactorial. Recent investigations suggest that management of patients based on low-flow theory does not lead to improved outcomes. Relative importance of right heart dysfunction (manifested as increased CVP) has not been evaluated . Precise understanding of bidirectional pathways by which the heart and kidneys influence each other is necessary to define optimal treatment strategies specific to the subtypes, as therapies directed towards one organ system may have beneficial or unfavorable effects on the other.
METHODS
研究设计
- 研究类型
- Observational
- 观察模型
- Other
- 时间视角
- Retrospective
入排标准
- 年龄范围
- 18 Years 至 100 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •HF (NYHA class I - IV, with preserved and reduced EF) and reduced GFR (Cardio-Renal Syndromes 1 and 2)
排除标准
- •Independent risk factors for renal impairment (e.g. diabetes, sepsis)
- •Primary nephropathy or secondary nephropathy due to diseases other than HF
结局指标
主要结局
renal impairment (defined as a Glomerular Filtration Rate less than 60 mL/min per 1.73 m2)
时间窗: through study completion, an average of 1 year
Estimated Glomerular Filtration Rate has been assessed with the Modification of Diet in Renal Disease formula
次要结局
未报告次要终点
研究者
George Lobzhanidze
MD
Tbilisi State University