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Clinical Trials/NCT01748006
NCT01748006UnknownNot Applicable

The Correlation Between Filling Pressure, Cardiac Output and Plasma Copeptin in Patients With Systolic Heart Failure

Finn Gustafsson1 site in 1 country30 target enrollmentStarted: June 2012Last updated:
Conditions

Trial Snapshot

Phase
Not Applicable
Sponsor
Enrollment
30
Locations
1
Primary Endpoint
The correlation between levels of plasma copeptin and vasopressin with left ventricular filling pressure and cardiac output

Study Overview

Brief Summary

The relationship between the activation of the vasopressin system and central hemodynamics in heart failure (including right and left heart filling pressures and cardiac output) is not clear. The investigators intend to examine the correlation between levels of copeptin and vasopressin and the central hemodynamic system in patients with advanced (class III or IV) heart failure. The investigators also aim to examine the relationship of selected cardiac biomarkers in blood and urine with cardiac filling pressures and cardiac output in patients with decompensated heart failure.

The study population will consist of 30 patients admitted to the Department of Cardiology at Copenhagen University Hospital. Only patients for whom the attending cardiologist has already decided upon right heart catheterization for clinical/treatment reasons will be recruited for the study.

Study Design

Study Type
Observational
Observational Model
Cohort
Time Perspective
Prospective

Eligibility Criteria

Ages
18 Years to 80 Years (Adult, Older Adult)
Sex
All
Accepts Healthy Volunteers
No

Inclusion Criteria

  • Age > 18 years
  • Left ventricular ejection fraction < 40 %
  • Diagnosed symptomatic heart failure treated with heart failure medications for at least 30 days.
  • Clinical indication for right heart catheterization for clinical/treatment reasons
  • NYHA-class III-IV
  • Relevant heart failure treatment as tolerated by the patient

Exclusion Criteria

  • Absence of clinical/treatment indication of right heart catheterization
  • Syndrome of Inappropriate Secretion of ADH (SIADH)
  • Recent acute myocardial infarction within the last 30 days
  • Presence of infection or inflammatory disease
  • Malignant disease
  • Subjects unwilling or unable to provide written consent

Outcomes

Primary Outcomes

The correlation between levels of plasma copeptin and vasopressin with left ventricular filling pressure and cardiac output

Time Frame: Day 1

Secondary Outcomes

  • The correlation between levels of plasma copeptin and vasopressin with urine aquaporin-2 concentration(Day 1)
  • The correlation between biomarkers levels and survival free of transplantation- and left ventricular assist device insertion(1 year)
  • The correlation between New York Heart Association (NYHA) class and levels of plasma copeptin and vasopressin(Day 1)

Investigators

Sponsor
Finn Gustafsson
Sponsor Class
Other
Responsible Party
Sponsor Investigator
Principal Investigator

Finn Gustafsson

MD, DMSc

Rigshospitalet, Denmark

Study Sites (1)

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