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临床试验/NCT01748006
NCT01748006Unknown不适用

The Correlation Between Filling Pressure, Cardiac Output and Plasma Copeptin in Patients With Systolic Heart Failure

Finn Gustafsson1 个研究点 分布在 1 个国家目标入组 30 人开始时间: 2012年6月最近更新:
适应症

试验速览

阶段
不适用
发起方
入组人数
30
试验地点
1
主要终点
The correlation between levels of plasma copeptin and vasopressin with left ventricular filling pressure and cardiac output

研究概览

简要总结

The relationship between the activation of the vasopressin system and central hemodynamics in heart failure (including right and left heart filling pressures and cardiac output) is not clear. The investigators intend to examine the correlation between levels of copeptin and vasopressin and the central hemodynamic system in patients with advanced (class III or IV) heart failure. The investigators also aim to examine the relationship of selected cardiac biomarkers in blood and urine with cardiac filling pressures and cardiac output in patients with decompensated heart failure.

The study population will consist of 30 patients admitted to the Department of Cardiology at Copenhagen University Hospital. Only patients for whom the attending cardiologist has already decided upon right heart catheterization for clinical/treatment reasons will be recruited for the study.

研究设计

研究类型
Observational
观察模型
Cohort
时间视角
Prospective

入排标准

年龄范围
18 Years 至 80 Years(Adult, Older Adult)
性别
All
接受健康志愿者

入选标准

  • Age > 18 years
  • Left ventricular ejection fraction < 40 %
  • Diagnosed symptomatic heart failure treated with heart failure medications for at least 30 days.
  • Clinical indication for right heart catheterization for clinical/treatment reasons
  • NYHA-class III-IV
  • Relevant heart failure treatment as tolerated by the patient

排除标准

  • Absence of clinical/treatment indication of right heart catheterization
  • Syndrome of Inappropriate Secretion of ADH (SIADH)
  • Recent acute myocardial infarction within the last 30 days
  • Presence of infection or inflammatory disease
  • Malignant disease
  • Subjects unwilling or unable to provide written consent

结局指标

主要结局

The correlation between levels of plasma copeptin and vasopressin with left ventricular filling pressure and cardiac output

时间窗: Day 1

次要结局

  • The correlation between levels of plasma copeptin and vasopressin with urine aquaporin-2 concentration(Day 1)
  • The correlation between biomarkers levels and survival free of transplantation- and left ventricular assist device insertion(1 year)
  • The correlation between New York Heart Association (NYHA) class and levels of plasma copeptin and vasopressin(Day 1)

研究者

发起方
Finn Gustafsson
申办方类型
Other
责任方
Sponsor Investigator
主要研究者

Finn Gustafsson

MD, DMSc

Rigshospitalet, Denmark

研究点 (1)

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