Juvenile Essential Arterial Hypertension and Vascular Reactivity in Systemic and Cerebral Circulation
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Child, Only
- Sponsor
- Josip Juraj Strossmayer University of Osijek
- Enrollment
- 50
- Locations
- 1
- Primary Endpoint
- Systemic microvascular function in children
- Last Updated
- 4 years ago
Overview
Brief Summary
The main goal of this study is to investigate the association of the juvenile essential arterial hypertension with systemic micro- and macrovascular reactivity and cerebral vascular function, and to examine the potential impact of elevated oxidative stress on this associations.
Investigators
Ines Drenjancevic
Head of Department of Physiology and Immunology Faculty of Medicine Osijek
Josip Juraj Strossmayer University of Osijek
Eligibility Criteria
Inclusion Criteria
- •healthy normotensive children and children with essential arterial hypertension
Exclusion Criteria
- •secondary arterial hypertension
- •other systemic diseases with immunopathology
- •neurodegenerative diseasesat
- •children that use therapy which has a high impact on vascular or immunological function (immunotherapy, immunosuppressive therapy, sistemic corticosteroid therapy etc..).
Outcomes
Primary Outcomes
Systemic microvascular function in children
Time Frame: Day 1.
Skin microvascular reactivity assessed by Laser Doppler flowmetry (post-occlusive reactive hyperemia, iontophoresis of acetylcholine and sodium nitroprusside) - measured in perfusion units (PU)
Systemic macrovascular function in children
Time Frame: Day 1.
Vascular ultrasound measurement of brachial artery response to vascular occlusion (flow mediated dilation; FMD, %)
Cerabral vascular function in children
Time Frame: Day 1.
Cerebral blood flow velocities assessed by transcranial Doppler sonography (cm/s)
Secondary Outcomes
- Endocan(Day 1.)
- Oxidative stress - thiobarbituric acid reactive substances (TBARS)(Day 1.)