Juvenile Essential Arterial Hypertension and Vascular Function

• Conditions: Child, Only; Essential Hypertension

• Registration Number: NCT05109013
• Lead Sponsor: Josip Juraj Strossmayer University of Osijek

Brief Summary

The main goal of this study is to investigate the association of the juvenile essential arterial hypertension with systemic micro- and macrovascular reactivity and cerebral vascular function, and to examine the potential impact of elevated oxidative stress on this associations.

Detailed Description

Not available

Study Timeline

• Study Start: 2021-09-01
• Study First Submitted: 2021-09-02
• Study First Submitted QC: 2021-10-25
• Status Verified: 2021-11
• Last Update Submitted: 2021-11-04
• Study First Posted: 2021-11-05
• Last Update Posted: 2021-11-11
• Primary Completion: 2022-12-31
• Study Completion: 2023-12-31

Recruitment & Eligibility

• Status: UNKNOWN
• Sex: All
• Target Recruitment: 50

Inclusion Criteria

• healthy normotensive children and children with essential arterial hypertension

Exclusion Criteria

• secondary arterial hypertension
• other systemic diseases with immunopathology
• neurodegenerative diseasesat
• children that use therapy which has a high impact on vascular or immunological function (immunotherapy, immunosuppressive therapy, sistemic corticosteroid therapy etc..).

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Systemic macrovascular function in children	Day 1.	Vascular ultrasound measurement of brachial artery response to vascular occlusion (flow mediated dilation; FMD, %)
Cerabral vascular function in children	Day 1.	Cerebral blood flow velocities assessed by transcranial Doppler sonography (cm/s)
Systemic microvascular function in children	Day 1.	Skin microvascular reactivity assessed by Laser Doppler flowmetry (post-occlusive reactive hyperemia, iontophoresis of acetylcholine and sodium nitroprusside) - measured in perfusion units (PU)

Secondary Outcome Measures

Name	Time	Method
Endocan	Day 1.	Serum sample collection for ELISA measurement of serum endocan level - proteoglycan associated with endothelium activation
Oxidative stress - thiobarbituric acid reactive substances (TBARS)	Day 1.	Serum sample collection for measurement of biomarkers of oxidative stress level. Thiobarbituric acid reactive substances (TBARS) - biomarker of lipid peroxidation.

Trial Locations

Locations (1)

Osijek University Hospital; 🇭🇷 Osijek, Croatia