Juvenile Essential Arterial Hypertension and Vascular Reactivity in Systemic and Cerebral Circulation
试验速览
- 阶段
- 不适用
- 入组人数
- 50
- 试验地点
- 1
- 主要终点
- Systemic microvascular function in children
研究概览
简要总结
The main goal of this study is to investigate the association of the juvenile essential arterial hypertension with systemic micro- and macrovascular reactivity and cerebral vascular function, and to examine the potential impact of elevated oxidative stress on this associations.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Control
- 时间视角
- Cross Sectional
入排标准
- 年龄范围
- 9 Years 至 18 Years（Child, Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •healthy normotensive children and children with essential arterial hypertension
排除标准
- •secondary arterial hypertension
- •other systemic diseases with immunopathology
- •neurodegenerative diseasesat
- •children that use therapy which has a high impact on vascular or immunological function (immunotherapy, immunosuppressive therapy, sistemic corticosteroid therapy etc..).
结局指标
主要结局
Systemic microvascular function in children
时间窗: Day 1.
Skin microvascular reactivity assessed by Laser Doppler flowmetry (post-occlusive reactive hyperemia, iontophoresis of acetylcholine and sodium nitroprusside) - measured in perfusion units (PU)
Systemic macrovascular function in children
时间窗: Day 1.
Vascular ultrasound measurement of brachial artery response to vascular occlusion (flow mediated dilation; FMD, %)
Cerabral vascular function in children
时间窗: Day 1.
Cerebral blood flow velocities assessed by transcranial Doppler sonography (cm/s)
次要结局
- Endocan(Day 1.)
- Oxidative stress - thiobarbituric acid reactive substances (TBARS)(Day 1.)
研究者
Ines Drenjancevic
Head of Department of Physiology and Immunology Faculty of Medicine Osijek
Josip Juraj Strossmayer University of Osijek