Haemodynamic determinants of hYpertension in Children and Young People and role of the sympathetic nervous system: HY CYP

King's College London0 个研究点目标入组 100 人开始时间: 2023年8月9日最近更新: 2023年8月21日

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•1. Aged 10-35 years old
•2. Primary hypertension (intervention group) or BP < 90th centile (control group)
•3. Able to tolerate the planned investigations
•4. Not currently on anti-hypertensive medication/s or able to stop anti-hypertensive medications for 2 weeks prior to any research-related assessments.
•Additional inclusion criteria control participants:
•5. BMI in the normal range for age

•1. Secondary hypertension
•2. Clinical urgency to commence anti-hypertensive or unable to stop anti-antihypertensives for 2 week washout period
•3. Unable to obtain adequate quality of planned cardiovascular investigations
•4. Congenital heart disease
•5. Cardiac dysrhythmias
•6. Pregnancy or lactating mothers
•Additional exclusion criteria for medication 1 (bisoprolol challenge):
•7. Asthma currently treated with medication
•8. Cardiac conduction abnormalities
•9. Known intolerance to bisoprolol
•Additional exclusion criteria for medication 2 (amlodipine challenge):
•10. History of angina or myocardial infarction
•11. Known intolerance to amlodipine

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