Application of Mesenchymal Stem Cells Derived Exosomes in Skin Rejuvenation
试验速览
- 阶段
- 1 期
- 状态
- 招募中
- 入组人数
- 20
- 试验地点
- 2
- 主要终点
- Proportion of re-epithelialization
研究概览
简要总结
Aging is a natural and complex process. The effect of environmental factors, genetics on the body eventually leads to damage in different ways. Exosomes are present in almost all body fluids, such as synovial fluid and blood. Exosomes and microvesicles are very efficient mediators of cell-to-cell communication by transferring their specific cargo to recipient cells; for example, exosomes are involved in the delivery of genetic materials, causing epigenetic modifications in the target cells .The applications of MSC-derived exosomes have more effect in cutaneous regeneration by collagen stimulation.The basic biology of exosomes indicates that MSC-exosomes may contain MSC-specific components to exert specific effects on recipient cells, which are somewhat equivalent to the regenerative effects of MSCs. This study aims to slow down the aging process of the skin by using exosome.
详细描述
Skin aging is a complex biological process that can be classified into extrinsic or intrinsic aging. Intrinsic aging is an intrinsic degradation process that is caused by a decrease in the proliferation capacity leading to cell senescence. Angiogenesis is essential in various physiological processes, including wound healing and skin tissue regeneration. Literature reviews show that exosomes derived from human umbilical cord blood mesenchymal stem cells can cause Collagen stimulation and reduction of oxidative stress, WNT/βcatenin pathway signaling in the initial stages of causes the regeneration of skin damage . This study aims to slow down the aging process of the skin by using exosome.
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Single Group
- 主要目的
- Prevention
- 盲法
- None
入排标准
- 年龄范围
- 35 Years 至 65 Years（Adult, Older Adult）
- 性别
- Female
- 接受健康志愿者
- 是
入选标准
- •Ages 35-65
- •Patients of all racial and ethnic origins
- •Patients of all undergoing facial rejuvenation
排除标准
- •Female patients in pregnancy or menstrual period
- •Patients undergoing facial rejuvenation using other methods including Botox injections, chemical peels, face lifts and others
- •Patients using blood thinners, aspirin and hormone, that cannot be stopped
- •Patients suffering with severe organic disease, such as coronary heart disease, hypertension, diabetes, lung dysfunction and so on
- •Patients suffering with mental disease, and acute or chronic infectious diseases
结局指标
主要结局
Proportion of re-epithelialization
时间窗: 3 months
In order to evaluate the treatment effect, to evaluate wrinkles and collagen before the treatment, take a photo/CT of the face
次要结局
未报告次要终点
研究者
Leila Dehghani
Principal Investigator
Isfahan University of Medical Sciences