Development of a Decision-making Aid for Referring Severe Kidney Injury Patients for Nephrology Consultations

Completed

• Conditions: Acute Kidney Injury; Chronic Kidney Diseases
• Interventions: Other: monitoring for progression to chronic kidney disease

• Registration Number: NCT03192189
• Lead Sponsor: Centre Hospitalier Universitaire de Nīmes

Brief Summary

Acute kidney injury is a frequent and growing complication associated with a risk of progressing into a chronic kidney disease. Recent guidelines have recommended systematic consultations with a nephrologist 3-6 months following hospitalization. Risk factors of developing chronic kidney disease between hospital visits are understudied.

Detailed Description

Not available

Study Timeline

• Study Start: 2016-08-20
• Study First Submitted: 2017-06-16
• Study First Submitted QC: 2017-06-16
• Study First Posted: 2017-06-20
• Primary Completion: 2017-12-31
• Study Completion: 2018-06
• Status Verified: 2018-07
• Last Update Submitted: 2021-11-03
• Last Update Posted: 2021-11-10

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 319

Inclusion Criteria

• Age >18 years
• Suffering from acute kidney injury treated with dialysis
• hospitalized in a university center from August 2016 to December 2017 with severe AKI defined according to 2 of the 3 criterion definitions of KDIGO stage AKI: an increase in SCr above 354 μmol/Lor renal replacement therapy (RRT) indication, but not the 3-fold increase in SCr increase within 7 days with SCr below 354 μmol/L.
• The patient has been informed and does not oppose the study
• The patient is insured or the beneficiary of a health insurance policy

Exclusion Criteria

• The patients is under judicial protection or state guardianship
• Patient has chronic kidney disease(CKD) KDIGO stage 5
• It proves impossible to give the patient clear information
• patients living with kidney transplant
• plan dialysis for bilateral surgery nephrectomy
• patient refuse to participate and patients with no health insurance

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
Patients with acute kidney injury	monitoring for progression to chronic kidney disease	Requiring treatment with dialysis

Primary Outcome Measures

Name	Time	Method
Develop a prognostic score of progression to chronic kidney disease at 6 months in patients requiring hospitalization for dialysis for acute kidney injury to identify those who would benefit from consultation with a nephrologist	6 months

Secondary Outcome Measures

Name	Time	Method
Identify new risk factors for progression to chronic kidney disease at 6 months post dialysis for acute kidney injury pre-hospitalization and during hospitalization and day of discharge	6 months
Identify renal phenotype of patients with chronic kidney disease	6 months	characterization from renal biopsy
Evaluate mortality during hospital stay	1 months
Evaluate mortality at medium-term	6 months
Identify specific therapeutic interventions put into place during the 6 month consultation	6 months

Trial Locations

Locations (1)

CHU Nimes; 🇫🇷 Nîmes, France