The Effect of Automated Electronic Alert for Acute Kidney Injury on the Outcomes of Hospitalized Patients

Not Applicable

Completed

• Conditions: Acute Kidney Injury; Outcomes; Early Diagnosis
• Interventions: Other: Usual care; Device: AKI alert

• Registration Number: NCT03736304
• Lead Sponsor: The First Affiliated Hospital with Nanjing Medical University

Brief Summary

Acute kidney injury (AKI) is a common disease, but diagnosis is usually delayed or missed in hospitalized patients. The automated electronic alert for AKI may help to improve the outcomes of these patients through identifying all cases of AKI early. Therefore, the investigators conduct a randomly controlled study to test whether automated electronic alert for AKI could improve the outcomes of hospitalized patients.

Detailed Description

Acute kidney injury (AKI) is a common disease, but diagnosis is usually delayed or missed in hospitalized patients. The automated electronic alert for AKI may help to improve the outcomes of these patients through identifying all cases of AKI early. Therefore, the investigators conduct a randomly controlled study to test whether automated electronic alert for AKI could improve the outcomes of hospitalized patients.

The patients were randomly divided into two groups:

Usual care : patients will receive standard clinical care by the primary physicians AKI alert : an AKI alert will be sent to the doctor in charge. The team of kidney experts would give a suggestion if the doctor in charge need a renal consultation.

Study Timeline

• Study First Submitted: 2018-11-08
• Study First Submitted QC: 2018-11-08
• Study First Posted: 2018-11-09
• Study Start: 2019-08-01
• Primary Completion: 2022-01-31
• Study Completion: 2022-01-31
• Status Verified: 2023-12
• Last Update Submitted: 2023-12-28
• Last Update Posted: 2024-01-02

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 4536

Inclusion Criteria

• Hospitalized adult patients with an Alert for AKI(based on KDIGO guidelines)

Exclusion Criteria

• Patients already having eGFR<15ml/min/1.73m2 or receiving renal replacement therapy for AKI at the time of alert.
• Patients already having a AKI before admission.

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
Usual care	Usual care	Patients will receive standard clinical care by the doctor in charge.
AKI alert	AKI alert	An AKI alert will send to the the doctor in charge. The team of nephrologists would give suggestions if the doctor in charge need a renal consultation.

Primary Outcome Measures

Name	Time	Method
Estimated glomerular filtration rate changed within 7 days	within 7 days diagnosed with AKI	Medical record

Secondary Outcome Measures

Name	Time	Method
30-day mortality	within 30 days diagnosed with AKI	Medical record
1-year mortality	within 1 year diagnosed with AKI	telephone follow-up
receiving renal replacement therapy at 30th day	30 days	telephone follow-up
the rate of stage 3 AKI	within 7 days diagnosed with AKI	Medical record
receiving renal replacement therapy at seventh day	7 days	Medical record
Follow-up rate after discharge	1 year	telephone follow-up
seven-day mortality	within 7 days diagnosed with AKI	Medical record
the interventions for AKI	within 7 days diagnosed with AKI	Medical record
receiving renal replacement therapy at 1 year	1 year	telephone follow-up
the rate of stage 2 AKI	within 7 days diagnosed with AKI	Medical record
the rate of AKI recovery at 90 day	90 days	telephone follow-up
the rate of timely-recognition of AKI	3 days	Medical record

Trial Locations

Locations (1)

Jiangsu Province Hospital; 🇨🇳 Nanjing, Jiangsu, China