Clinical Values of Automated Electronic Alert for Acute Kidney Injury

Not Applicable

Completed

• Conditions: Acute Kidney Injury
• Interventions: Device: AKI alert

• Registration Number: NCT02793167
• Lead Sponsor: XinLing Liang

Brief Summary

Acute kidney injury (AKI) is common, serious and expensive.It is associated with significant mortality, morbidity and increased length of hospital stay.To improve clinical outcomes of AKI by early detection and timely referral to the renal,the investigators developed an electronic alert system which identifies all cases of AKI occurring in patients over 18 years.The system was also designed to collect data on AKI incidence one of the biggest tertiary hospital in China.

Detailed Description

A prospective, randomly controlled cohort study will be conducted agmong the patients with AKI who are detected by the use of AKI sniffer. The investigators chose to assess all inpatient serum creatinine results using a combination of "KDIGO" criteria.

The investigators randomly divided the patients into two groups:

1. Usual care : patients will receive standard clinical care by the primary physicians

2. AKI alert : an AKI alert will be sent to the the doctor in charge. Our team of kidney experts would give a suggestion if the the doctor in charge issue consultation applications.

Study Timeline

• Study Start: 2016-03
• Study First Submitted: 2016-05-23
• Study First Submitted QC: 2016-06-07
• Study First Posted: 2016-06-08
• Primary Completion: 2021-12
• Study Completion: 2022-06
• Status Verified: 2023-02
• Last Update Submitted: 2023-02-21
• Last Update Posted: 2023-02-23

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 2000

Inclusion Criteria

• adult patients with an Alert for AKI(based on KDIGO guidelines)

Exclusion Criteria

• patients already on dialysis for AKI at the time of alert
• patients with End stage renal disease
• patients <18 years of age
• patients dissenting from participation according to the Ethics application

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
AKI alert	AKI alert	an AKI alert will send to the the doctor in charge.Our team of nephrologists would give suggestions if the doctor in charge issue consultation application.

Primary Outcome Measures

Name	Time	Method
Adverse events during hospitalization	from start of AKI to discharge,up to 4 weeks	cardiac shock/ need for intensive care/ cardiopulmonary resuscitation/ cardiac death/ death
Incidence of cardiovascular disease and its occurrence time followed up for 1 years	One year after discharge	heart failure/ acute coronary syndrome/ readmission/cardiac readmission/ cardiovascular intervention or surgery
AKI recovery/stop renal replacement therapy	from start of AKI to discharge,up to 4 weeks	Glomerular filtration rate decreased/ new occurrence proteinuria/ original proteinuria aggravation
The AKI outcome and its occurrence time followed up for 1 years	One year after discharge	AKI recovery/stop renal replacement therapy

Secondary Outcome Measures

Name	Time	Method
Follow-up rate after discharge	One year after discharge
Proportion of nephrology referral	from start of AKI to discharge,up to 4 weeks
Diagnostic rate of AKI at discharge	from start of AKI to discharge,up to 4 weeks

Trial Locations

Locations (1)

Nephrology Dept,Guangdong General Hospital; 🇨🇳 Guangzhou, Guangdong, China