Effect of General Anesthesia on Early Postoperative Cognitive Dysfunction in Elective Versus Emergency Cesarean Section
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 58
- 试验地点
- 1
- 主要终点
- postoperative cognitive decline (POCD)
研究概览
简要总结
Cognitive dysfunction is the impairment of the mental process of perception, memory and information processing. The preoperative cognitive state is important, as mild cognitive impairment may be worsened following a cesarean section. Our study will aim to assess the incidence of early cognitive dysfunction after elective and emergent cesarean section under general anesthesia.
详细描述
Mechanisms that lead to cognitive decline after anesthesia and surgery remain still unclear and mixed. Some studies suggested that an important role is played by the immune response to surgery. The inflammatory response could contribute to the development of postoperative cognitive decline (POCD0 through secretion of cortisol, cytokines, and other inflammatory mediators. Comparing the effects of general and spinal anesthesia on pregnant patients undergoing an elective cesarean section, found no cognitive change after both anesthesias. Our observational comparative study will be carried out at Beni Suef University Hospital. We will compare early cognitive functions undergoing general anesthesia in patients undergoing elective and emergency cesarean section.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 25 Years 至 35 Years（Adult）
- 性别
- Female
- 接受健康志愿者
- 否
入选标准
- •Women in reproductive age period between 25 and 35 years
- •Women booked for an elective or emergency cesarean section.
排除标准
- •Mental disorder preoperative
- •Medical conditions ( as Hypertension or diabetes or cardiac diseases)
结局指标
主要结局
postoperative cognitive decline (POCD)
时间窗: 3 hours postoperative
New impairment of memory directly post operative which will be assessed by psychometric questionnaire
次要结局
- impaired performance on intellectual tasks(3 days postoperative)
研究者
Nesreen Abdel Fattah Abdullah Shehata
Assistant professor
Beni-Suef University