Effect of General Anesthesia on Early Postoperative Cognitive Function in Cesarean Section

Completed

• Conditions: Anesthesia Morbidity; Cesarean Section Complications
• Interventions: Other: Assessment document

• Registration Number: NCT03818009
• Lead Sponsor: Beni-Suef University

Brief Summary

Cognitive dysfunction is the impairment of the mental process of perception, memory and information processing. The preoperative cognitive state is important, as mild cognitive impairment may be worsened following a cesarean section. Our study will aim to assess the incidence of early cognitive dysfunction after elective and emergent cesarean section under general anesthesia.

Detailed Description

Mechanisms that lead to cognitive decline after anesthesia and surgery remain still unclear and mixed. Some studies suggested that an important role is played by the immune response to surgery. The inflammatory response could contribute to the development of postoperative cognitive decline (POCD0 through secretion of cortisol, cytokines, and other inflammatory mediators. Comparing the effects of general and spinal anesthesia on pregnant patients undergoing an elective cesarean section, found no cognitive change after both anesthesias. Our observational comparative study will be carried out at Beni Suef University Hospital. We will compare early cognitive functions undergoing general anesthesia in patients undergoing elective and emergency cesarean section.

Study Timeline

• Study Start: 2019-01-14
• Study First Submitted: 2019-01-20
• Study First Submitted QC: 2019-01-23
• Study First Posted: 2019-01-28
• Primary Completion: 2020-09-20
• Study Completion: 2020-09-20
• Status Verified: 2020-11
• Last Update Submitted: 2020-11-16
• Last Update Posted: 2020-11-17

Recruitment & Eligibility

• Status: COMPLETED
• Sex: Female
• Target Recruitment: 58

Inclusion Criteria

• Women in reproductive age period between 25 and 35 years
• Women booked for an elective or emergency cesarean section.

Exclusion Criteria

• Mental disorder preoperative
• Medical conditions ( as Hypertension or diabetes or cardiac diseases)

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
women undergoing elective CS under general anesthesia	Assessment document	Early postoperative assessment of the cognitive function of patients through evaluation document which will be filled by the anesthesiologist.
women undergoing emergency CS under general anesthesia	Assessment document	Early postoperative assessment of the cognitive function of patients through evaluation document which will be filled by the anesthesiologist.

Primary Outcome Measures

Name	Time	Method
postoperative cognitive decline (POCD)	3 hours postoperative	New impairment of memory directly post operative which will be assessed by psychometric questionnaire

Secondary Outcome Measures

Name	Time	Method
impaired performance on intellectual tasks	3 days postoperative	New impairment of using mind in daily tasks directly post operative which will be assessed through a questionnaire

Trial Locations

Locations (1)

Nesreen Abdel Fattah Abdullah Shehata; 🇪🇬 Cairo, Egypt