The Effects of Anesthetics on Brain Network Connectivity in Patients With Supratentorial Glioma

Recruiting

• Conditions: Brain Network Connectivity; Dexmedetomidine; Propofol; Postoperative Delirium
• Interventions: Drug: Dexmedetomidine; Drug: Propofol; Drug: Remimazolam Injection

• Registration Number: NCT06138340
• Lead Sponsor: Beijing Tiantan Hospital

Brief Summary

Perioperative anesthesia can affect postoperative cognitive function. In our previous study, intraoperative dexmedetomidine (Dex) infusion reduced the incidence of delirium within the first 5 days after brain tumor. However, the mechanism is still unclear. With the development of neuroimaging, multimodal neuroimaging technology provide a new method to explore the underlying mechanism. Therefore, the purpose of this study is to analyze the alterations of brain network under sedation and anesthesia by different anesthetics in patients with supratentorial glioma and their association with cognition.

Detailed Description

Not available

Study Timeline

• Study Start: 2023-08-31
• Study First Submitted: 2023-09-11
• Study First Submitted QC: 2023-11-16
• Study First Posted: 2023-11-18
• Status Verified: 2025-02
• Last Update Submitted: 2025-02-12
• Last Update Posted: 2025-02-14
• Primary Completion: 2025-11-30
• Study Completion: 2025-12-31

Recruitment & Eligibility

• Status: RECRUITING
• Sex: All
• Target Recruitment: 120

Inclusion Criteria

• Diagnosed as unilateral supratentorial glioma by MRI
• Selective operation
• Age over 18 years old
• ASA I-II
• Right handedness

Exclusion Criteria

• History of cerebrovascular disease, brain trauma, chemotherapy and radiotherapy, or psychotropic drugs
• History of intracranial surgery
• Drug and/or alcohol abuse
• History of dementia or mental illness
• Pregnant or lactating women
• Contraindications for MRI
• Severe bradycardia (heart rate less than 40 beats per minute), sick sinus syndrome or second-to-third degree atrioventricular block
• Severe hepatic or renal dysfunction

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
Dex group	Dexmedetomidine	Participants will be sedated and maintained by dexmedetomidine.
Propofol group	Propofol	Participants will be sedated and maintained by propofol.
Remimazolam group	Remimazolam Injection	Participants will be sedated and maintained by remimazolam.

Primary Outcome Measures

Name	Time	Method
The alterations of brain network connectivity.	Before sedation, 30 minutes after sedation，and 30 minutes after surgery.	fMRI and DTI will be used to detect brain network connectivity.

Secondary Outcome Measures

Name	Time	Method
Electroencephalogram changes	From patients admission to operation room until 10 minutes after surgery	Electroencephalogram will be used to record the brain activity.
rScO2 changes.	From patients admission to operation room until 10 minutes after surgery	Regional cerebral oxygen saturation (rScO2) will be monitored with near-infrared spectroscopy (NIRS).
Postoperative delirium.	Day 1-5 after surgery.	The incidence and severity of postoperative delirium and its association with changes of brain network connectivity.

Trial Locations

Locations (1)

Beijing Tian Tan Hospital, Capital Medical University; 🇨🇳 Beijing, Beijing, China