The Alterations of Brain Network Connectivity Under Sedation and Anesthesia in Patients With Supratentorial Glioma
Overview
- Phase
- Not Applicable
- Intervention
- Dexmedetomidine
- Conditions
- Brain Network Connectivity
- Sponsor
- Beijing Tiantan Hospital
- Enrollment
- 120
- Locations
- 1
- Primary Endpoint
- The alterations of brain network connectivity.
- Status
- Recruiting
- Last Updated
- last year
Overview
Brief Summary
Perioperative anesthesia can affect postoperative cognitive function. In our previous study, intraoperative dexmedetomidine (Dex) infusion reduced the incidence of delirium within the first 5 days after brain tumor. However, the mechanism is still unclear. With the development of neuroimaging, multimodal neuroimaging technology provide a new method to explore the underlying mechanism. Therefore, the purpose of this study is to analyze the alterations of brain network under sedation and anesthesia by different anesthetics in patients with supratentorial glioma and their association with cognition.
Investigators
Yuming Peng
Deputy chief of Department of Anesthesiology
Beijing Tiantan Hospital
Eligibility Criteria
Inclusion Criteria
- •Diagnosed as unilateral supratentorial glioma by MRI
- •Selective operation
- •Age over 18 years old
- •Right handedness
Exclusion Criteria
- •History of cerebrovascular disease, brain trauma, chemotherapy and radiotherapy, or psychotropic drugs
- •History of intracranial surgery
- •Drug and/or alcohol abuse
- •History of dementia or mental illness
- •Pregnant or lactating women
- •Contraindications for MRI
- •Severe bradycardia (heart rate less than 40 beats per minute), sick sinus syndrome or second-to-third degree atrioventricular block
- •Severe hepatic or renal dysfunction
Arms & Interventions
Dex group
Participants will be sedated and maintained by dexmedetomidine.
Intervention: Dexmedetomidine
Propofol group
Participants will be sedated and maintained by propofol.
Intervention: Propofol
Remimazolam group
Participants will be sedated and maintained by remimazolam.
Intervention: Remimazolam Injection
Outcomes
Primary Outcomes
The alterations of brain network connectivity.
Time Frame: Before sedation, 30 minutes after sedation，and 30 minutes after surgery.
fMRI and DTI will be used to detect brain network connectivity.
Secondary Outcomes
- Electroencephalogram changes(From patients admission to operation room until 10 minutes after surgery)
- rScO2 changes.(From patients admission to operation room until 10 minutes after surgery)
- Postoperative delirium.(Day 1-5 after surgery.)