The Alterations of Brain Network Connectivity Under Sedation and Anesthesia in Patients With Supratentorial Glioma
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 发起方
- 入组人数
- 120
- 试验地点
- 1
- 主要终点
- The alterations of brain network connectivity.
研究概览
简要总结
Perioperative anesthesia can affect postoperative cognitive function. In our previous study, intraoperative dexmedetomidine (Dex) infusion reduced the incidence of delirium within the first 5 days after brain tumor. However, the mechanism is still unclear. With the development of neuroimaging, multimodal neuroimaging technology provide a new method to explore the underlying mechanism. Therefore, the purpose of this study is to analyze the alterations of brain network under sedation and anesthesia by different anesthetics in patients with supratentorial glioma and their association with cognition.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Diagnosed as unilateral supratentorial glioma by MRI
- •Selective operation
- •Age over 18 years old
- •Right handedness
排除标准
- •History of cerebrovascular disease, brain trauma, chemotherapy and radiotherapy, or psychotropic drugs
- •History of intracranial surgery
- •Drug and/or alcohol abuse
- •History of dementia or mental illness
- •Pregnant or lactating women
- •Contraindications for MRI
- •Severe bradycardia (heart rate less than 40 beats per minute), sick sinus syndrome or second-to-third degree atrioventricular block
- •Severe hepatic or renal dysfunction
研究组 & 干预措施
Dex group
Participants will be sedated and maintained by dexmedetomidine.
干预措施: Dexmedetomidine (Drug)
Propofol group
Participants will be sedated and maintained by propofol.
干预措施: Propofol (Drug)
Remimazolam group
Participants will be sedated and maintained by remimazolam.
干预措施: Remimazolam Injection (Drug)
结局指标
主要结局
The alterations of brain network connectivity.
时间窗: Before sedation, 30 minutes after sedation，and 30 minutes after surgery.
fMRI and DTI will be used to detect brain network connectivity.
次要结局
- Electroencephalogram changes(From patients admission to operation room until 10 minutes after surgery)
- rScO2 changes.(From patients admission to operation room until 10 minutes after surgery)
- Postoperative delirium.(Day 1-5 after surgery.)
研究者
Yuming Peng
Deputy chief of Department of Anesthesiology
Beijing Tiantan Hospital