Rapid Versus Slow Ingestion of Mixed Meal: Influence on Islet and Incretin Hormone Secretion in Healthy Volunteers

Not Applicable

Completed

• Conditions: Healthy Volunteers Recruited From the General Population
• Interventions: Other: Mixed meal

• Registration Number: NCT01779622
• Lead Sponsor: Lund University

Brief Summary

To test the influence of rapid versus slow ingestion of a mixed meal on insulin and incretin hormone secretion in healthy volunteers

Detailed Description

A mixed meal (524 kcal) is ingested rapidly (within 5 min) or slowly (10-15 min) and changes in insulin, glucagon, GIP and GLP-1 levels are followed for subsequent 300 min

Study Timeline

• Study First Submitted: 2013-01-27
• Study First Submitted QC: 2013-01-29
• Study First Posted: 2013-01-30
• Study Start: 2013-06
• Primary Completion: 2014-01
• Study Completion: 2014-06
• Status Verified: 2014-09
• Last Update Submitted: 2014-09-29
• Last Update Posted: 2014-09-30

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 24

Inclusion Criteria

• Healthy subjects

Exclusion Criteria

• Diabetes Liver disease Kidney disease Thyroid disease

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: SINGLE_GROUP

Arm && Interventions

Group	Intervention	Description
1	Mixed meal	Healthy volunteers are ingesting a mixed meal either rapidly or slowly

Primary Outcome Measures

Name	Time	Method
Area under the curve for insulin	300 min

Secondary Outcome Measures

Name	Time	Method
Area under the curve for glucose-dependent insuinotropic polypeptide	300 min
Area under the curve for glucagon-like peptide-1	300 min

Trial Locations

Locations (1)

Department of Clinical Sciences, Lund University; 🇸🇪 Lund, Sweden