Fronto-limbic Functional Connectivity Via Real-time fMRI Neurofeedback

Not Applicable

Completed

• Conditions: Healthy
• Interventions: Device: Real-time fMRI neurofeedback from Turbo Brain voyager (TBV) 3.2

• Registration Number: NCT02692196
• Lead Sponsor: University of Electronic Science and Technology of China

Brief Summary

Real-time fMRI neurofeedback training induced volitional control of brain activity and connectivity could help individuals to gain better control over their emotions.

Detailed Description

In the present proof-of-concept study, investigators plan to evaluate whether real-time fMRI neurofeedback training can enable individuals to gain volitional control over their fronto-limbic circuitry. Given that this circuitry has been abundantly implicated in emotional perception and regulation this could facilitate emotional control. Suitable participants underwent fronto-limbic connectivity feedback training and sham training in a cross over design. During both trainings participants are instructed to regulate the neural indices during feedback. We expect that receiving fronto-limbic feedback enhances emotion regulation during the training.

Study Timeline

• Study Start: 2015-06
• Study First Submitted: 2016-02-17
• Study First Submitted QC: 2016-02-22
• Study First Posted: 2016-02-25
• Primary Completion: 2016-10
• Study Completion: 2016-11
• Status Verified: 2017-11
• Last Update Submitted: 2017-11-07
• Last Update Posted: 2017-11-08

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 24

Inclusion Criteria

• healthy subjects without past or current psychiatric or neurological disorders

Exclusion Criteria

• pregnant, taking oral contraceptives

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: CROSSOVER

Arm && Interventions

Group	Intervention	Description
Sham Control	Real-time fMRI neurofeedback from Turbo Brain voyager (TBV) 3.2	Sham training - feedback that is not related with fronts-limbic connectivity (motor connectivity)
Neurofeedback Training	Real-time fMRI neurofeedback from Turbo Brain voyager (TBV) 3.2	Neurofeedback training - neurofeedback of fronto-limbic functional connectivity.

Primary Outcome Measures

Name	Time	Method
Neural indices of training success	three days
Training-induced changes in emotion related processing	three days	The scores of visual analogue scale assessing individuals' anxiety level will be compared between before and after training within each group as well as between twe groups after training

Trial Locations

Locations (1)

School of Life Science and Technology, University of Electronic Science and Technology of China; 🇨🇳 Chengdu, Sichuan, China