NCT02882568
Completed
Not Applicable
Analysis of Immune Response In Bacterial Infection of Obese Subject
Versailles Hospital1 site in 1 country15 target enrollmentAugust 2014
ConditionsObesity
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Obesity
- Sponsor
- Versailles Hospital
- Enrollment
- 15
- Locations
- 1
- Primary Endpoint
- Patterns of inflammatory and immunological markers in obese patients in sepsis and post- sepsis ("normal") situation
- Status
- Completed
- Last Updated
- 8 years ago
Overview
Brief Summary
Improve knowledge of the immune response to sepsis in obese patients. Define immunological and genetic prognostic factors of severe infections which can motivate a change in the therapeutic attitude
Investigators
Roderick Meckenstock
Dr
Versailles Hospital
Eligibility Criteria
Inclusion Criteria
- •between18 and 80 years
- •obesity: BMI \> 30
- •presumed bacterial infection:
- •pneumonitis (documented or probably)
- •pyelonephritis / acute prostatitis
- •soft tissue / skin infection (except for bedsore)
- •cholecystitis / angiocholitis
- •meningitis
- •clostridium colitis
- •surgical site infection
Exclusion Criteria
- •patients with viral, parasitic or mycotic documented infection
- •patients with bacterial infection with treatment\> 4 weeks (ex. endocarditis; osteo- articular infections)
- •patients with prior antibiotic treatment (\< 14 days)
- •intensive care unit patients
- •patients with a history of cancer or malignant hematological disease within the 5 previous years that is currently clinically significant (non metastatic prostatic and basocellular malignancy are excluded)
- •patients with systemic disease
- •Known diagnosis of human immunodeficiency infection (DICV, HIV...)
- •immunosuppression treatment during last month including corticotherapy
- •pregnancy
- •3 months follow up not possible
Outcomes
Primary Outcomes
Patterns of inflammatory and immunological markers in obese patients in sepsis and post- sepsis ("normal") situation
Time Frame: T 0 and at 1 month
Standard inflammatory markers; immunological markers (cytokines, leptine, lymphocyte phenotype)
Secondary Outcomes
- Analysis of leptine polymorphism(1 month)
- Evaluation of sepsis; correlation with inflammatory and immunological parameters(T 0 and at 1 month)
Study Sites (1)
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