The effect of anterior cruciate ligament injury on skeletal muscle function, contractile proteins and inflammatio
Not Applicable
Completed
- Conditions
- Anterior cruciate ligament injuryMusculoskeletal - Other muscular and skeletal disorders
- Registration Number
- ACTRN12613000157774
- Lead Sponsor
- Victoria University
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- All
- Target Recruitment
- 12
Inclusion Criteria
ACL group:
1. Scheduled for ACL reconstructive surgery.
2. Between 18-35 years of age
3. BMI <30
Control Group:
1. Free from lower limb injury
2. Between 18-35 years of age
3. BMI <30
Exclusion Criteria
ACL group:
Not between 18-35 years of age.
Any metabolic or cardiovascular diseases which impact on physical activity prior to ACL injury.
Control group
Not between 18-35 years of age
Any metabolic or cardiovascular diseases which impact on physical activity levels
Recent lower limb joint injury
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Muscle Na+,K+ ATPase transport protein content. Measured using radioactive labelled ouabain binding site content for total functional Na+,K+ ATPase content, and western blotting for indivividual isoform content.[Immediately before the commencement of ACL reconstructive surgery.];Muscle function (strength and balance). Isometric strength measured using a portable force transducer strapped to a chair at 90 degree knee flexion.<br><br>Balance will be assessed using a force platform which can calculate the average velocity of the participant's centre of pressure. [Approximately 1-2 weeks before ACL reconstructive surgery.]
- Secondary Outcome Measures
Name Time Method Muscle inflammatory factors (IL-6, TNF alpha). This will be assessed using a Multiplex suspension array system (Bio-Rad). [Immediately before ACL reconstructive surgery.]