Virtual Reality Exposure Therapy in the Intensive Treatment of Social Anxiety Disorder

Not Applicable

• Conditions: Phobia
• Interventions: Device: vert; Drug: Sertraline

• Registration Number: NCT04977544
• Lead Sponsor: Second Affiliated Hospital, School of Medicine, Zhejiang University

Brief Summary

To explore the efficacy of drugs combined with virtual reality exposure therapy in the treatment of phobias compared with single drug treatment.

Detailed Description

Not available

Study Timeline

• Study Start: 2019-09-01
• Status Verified: 2021-06
• Study First Submitted: 2021-06-20
• Study First Submitted QC: 2021-07-25
• Last Update Submitted: 2021-07-25
• Study First Posted: 2021-07-27
• Last Update Posted: 2021-07-27
• Primary Completion: 2022-09-01
• Study Completion: 2022-09-01

Recruitment & Eligibility

• Status: UNKNOWN
• Sex: All
• Target Recruitment: 200

Inclusion Criteria

• Meet the diagnostic criteria for phobias in DSM-IV.
• Age from 18 to 45 years old.
• Graduated from junior high school or above.
• No serious physical disease, no serious visual impairment, and no family history of mental illness.

Exclusion Criteria

• Exclude other psychiatric diagnosis and treatment history.

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
vert combine with drug	vert	On the basis of sertraline drug treatment, phobia patients were given 2d/times from the 5th week, each 35-45min VR exposure treatment, 15 times as a course of treatment.
drug only	Sertraline	Sertraline was given as a single drug, with an initial dose of 50 mg/d, and gradually increased to the maximum dose of 200 mg/d after 2 weeks. The treating physician will determine the specific dose adjustment according to the patient's condition.
vert combine with drug	Sertraline	On the basis of sertraline drug treatment, phobia patients were given 2d/times from the 5th week, each 35-45min VR exposure treatment, 15 times as a course of treatment.

Primary Outcome Measures

Name	Time	Method
the level of anxiety	3 months	the score of Hamilton anxiety scale, the minimum and maximum values are 0 and 56, and higher scores mean a worse outcome.
heart rate of the patients	3 months	take the heart rate as a biomarker of fear, the faster heart rate means the participate is more afraid

Trial Locations

Locations (1)

The Fourth Affiliated Hospital of Zhejiang University Medical College; 🇨🇳 Yiwu, Zhejiang, China