跳至主要内容
临床试验/NCT04668391
NCT04668391已完成不适用

Ultrasound-guided Anterior Quadratus Lumborum Block at the Lateral Supra-arcuate Ligament Versus Thoracic Epidural Analgesia After Open Liver Surgery: A Prospective, Randomized, Controlled, Noninferiority Trial

Zhejiang Cancer Hospital1 个研究点 分布在 1 个国家目标入组 74 人开始时间: 2020年12月17日最近更新:
适应症

试验速览

阶段
不适用
状态
已完成
入组人数
74
试验地点
1
主要终点
NRS (numeric rating scale) score for coughing pain

研究概览

简要总结

This is a prospective, randomized, controlled, noninferiority trial for evaluating the efficacy of ultrasound-guided anterior quadratus lumborum block at the lateral supra-arcuate ligament versus thoracic epidural analgesia after open liver surgery.

研究设计

研究类型
Interventional
分配方式
Randomized
干预模型
Parallel
主要目的
Treatment
盲法
None

入排标准

年龄范围
18 Years 至 —(Adult, Older Adult)
性别
All
接受健康志愿者

入选标准

  • Age≥18 years
  • ASA I-III
  • Open liver surgery

排除标准

  • Contraindication to nerve block or epidural puncture
  • Chronic use of opioids or NSAIDs
  • Refused to participate in the study

结局指标

主要结局

NRS (numeric rating scale) score for coughing pain

时间窗: at 24 hours after surgery

Postoperative pain was assessed by NRS score with a range of 0 to 10 (0=no pain, 10=the worst possible pain)

次要结局

  • The incidence of pruritus(during 72 hours after surgery)
  • NRS score for rest and coughing pain(at 1, 6, 24, 48, 72 hours after surgery)
  • Time to eat in days(through study completion, an average of 2-3 days)
  • Time to defecation in hours(through study completion, an average of 60-70 hours)
  • Postoperative hospital stay in days(through study completion, an average of 7-8 days)
  • Clavien-Dindo classification (grade I, II, III, IV) for postoperative complication(One month after surgery)
  • Numbers of additional analgesics(during 72 hours after surgery)
  • The incidence of postoperative hypotension(during 72 hours after surgery)
  • The incidence of nausea and vomiting(during 72 hours after surgery)
  • Time to urethral catheter removal in hours(through study completion, an average of 60-70 hours)
  • The incidence of respiratory depression(during 72 hours after surgery)
  • consumption of opioid converted to IV morphine equivalents(during 24 hours after surgery)
  • Time to ambulation in days(through study completion, an average of 2-3 days)
  • Time to flatus in hours(through study completion, an average of 40-50 hours)

研究者

申办方类型
Other
责任方
Principal Investigator
主要研究者

Huifang Jiang

Principal Investigator

Zhejiang Cancer Hospital

研究点 (1)

Loading locations...

相似试验