Ultrasound-guided Anterior Quadratus Lumborum Block at the Lateral Supra-arcuate Ligament Versus Thoracic Epidural Analgesia After Open Liver Surgery: A Prospective, Randomized, Controlled, Noninferiority Trial

Zhejiang Cancer Hospital1 site in 1 country74 target enrollmentDecember 17, 2020

ConditionsLiver Surgery

Overview

Phase: Not Applicable
Intervention: Not specified
Conditions: Liver Surgery
Sponsor: Zhejiang Cancer Hospital
Enrollment: 74
Locations: 1
Primary Endpoint: NRS (numeric rating scale) score for coughing pain
Status: Completed
Last Updated: 3 years ago

Overview Investigators Eligibility Criteria Outcomes Sites Similar Trials

Overview

Brief Summary

This is a prospective, randomized, controlled, noninferiority trial for evaluating the efficacy of ultrasound-guided anterior quadratus lumborum block at the lateral supra-arcuate ligament versus thoracic epidural analgesia after open liver surgery.

Registry

clinicaltrials.gov

Start Date

December 17, 2020

End Date

July 2, 2021

Last Updated

3 years ago

Study Type

Interventional

Study Design

Parallel

Sex

All

Investigators

Sponsor

Zhejiang Cancer Hospital

Responsible Party

Principal Investigator

Huifang Jiang

Principal Investigator

Zhejiang Cancer Hospital

Eligibility Criteria

Inclusion Criteria

•Age≥18 years
•ASA I-III
•Open liver surgery

Exclusion Criteria

•Contraindication to nerve block or epidural puncture
•Chronic use of opioids or NSAIDs
•Refused to participate in the study

Outcomes

Primary Outcomes

NRS (numeric rating scale) score for coughing pain

Time Frame: at 24 hours after surgery

Postoperative pain was assessed by NRS score with a range of 0 to 10 (0=no pain, 10=the worst possible pain)

Secondary Outcomes

The incidence of pruritus(during 72 hours after surgery)
NRS score for rest and coughing pain(at 1, 6, 24, 48, 72 hours after surgery)
Time to eat in days(through study completion, an average of 2-3 days)
Time to defecation in hours(through study completion, an average of 60-70 hours)
Postoperative hospital stay in days(through study completion, an average of 7-8 days)
Clavien-Dindo classification (grade I, II, III, IV) for postoperative complication(One month after surgery)
Numbers of additional analgesics(during 72 hours after surgery)
The incidence of postoperative hypotension(during 72 hours after surgery)
The incidence of nausea and vomiting(during 72 hours after surgery)
Time to urethral catheter removal in hours(through study completion, an average of 60-70 hours)
The incidence of respiratory depression(during 72 hours after surgery)
consumption of opioid converted to IV morphine equivalents(during 24 hours after surgery)
Time to ambulation in days(through study completion, an average of 2-3 days)
Time to flatus in hours(through study completion, an average of 40-50 hours)