Ultrasound-guided Continous Quadratus Lumborum Block: Effect on Acute Pain and Quality of Recovery After Hepatic Surgery With Right Subcostal Incision
Overview
- Phase
- Not Applicable
- Intervention
- Continous QLB (quadratus lumborum block)
- Conditions
- Hepatectomy
- Sponsor
- Cui Xulei
- Enrollment
- 40
- Locations
- 1
- Primary Endpoint
- Cumulative morphine consumption
- Status
- Terminated
- Last Updated
- 6 years ago
Overview
Brief Summary
This prospective, randomized study, control study aims to compare the analgesic effect, opioids consumption, quality of recovery, length of hospital stay and et al. between unilateral continuous quadratus lumborum block (QLB) and intravenous patient-controlled analgesia (IPCA) alone in patients undergoing hepatectomy with right J-shape subcostal incision.
Investigators
Cui Xulei
Attending Physician
Peking Union Medical College Hospital
Eligibility Criteria
Inclusion Criteria
- •Age 18-70 yrs
- •American Society of Anesthesiologists physical statusⅠ-Ⅲ
- •Undergo hepatectomy with right J-shape subcostal incision
- •Informed consent
Exclusion Criteria
- •A known allergy to the drugs being used
- •Coagulopathy, on anticoagulants
- •Analgesics intake, history of substance abuse
- •Participating in the investigation of another experimental agent
- •Inability to properly describe postoperative pain to investigators (eg, language barrier, neuropsychiatric disorder)
Arms & Interventions
Continuous QLB+postoperative IPCA
Single-injection of QLB (quadratus lumborum block) is given preoperatively followed with continuous infusion+ postoperative IPCA (intravenous patient control analgesia)
Intervention: Continous QLB (quadratus lumborum block)
Continuous QLB+postoperative IPCA
Single-injection of QLB (quadratus lumborum block) is given preoperatively followed with continuous infusion+ postoperative IPCA (intravenous patient control analgesia)
Intervention: Philip CX50 Ultrasound Scanner
Continuous QLB+postoperative IPCA
Single-injection of QLB (quadratus lumborum block) is given preoperatively followed with continuous infusion+ postoperative IPCA (intravenous patient control analgesia)
Intervention: Ropivacaine
Continuous QLB+postoperative IPCA
Single-injection of QLB (quadratus lumborum block) is given preoperatively followed with continuous infusion+ postoperative IPCA (intravenous patient control analgesia)
Intervention: Morphine given as IPCA
IPCA
Postoperative IPCA (intravenous patient control analgesia) is given alone
Intervention: Morphine given as IPCA
Outcomes
Primary Outcomes
Cumulative morphine consumption
Time Frame: at 24 postoperative hours
Secondary Outcomes
- Time of recovery of bowl movement(within the 7 days after surgery)
- Quality of recovery(3 days and 7 days after surgery)
- Nausea and Vomiting score(At 0, 2,4, 8, 12, 24 and 48 hours after the surgery)
- Ambulation time(within the 7 days after surgery)
- Patient satisfaction with anesthesia(48 hours after surgery)
- Postoperative hospital length of stay(Up to 6 weeks)
- Pruritus score(At 0, 2,4, 8, 12, 24 and 48 hours after the surgery)
- The pain scores determined by the numeric rating scale (NRS, 0-10)(At 0, 2,4, 8, 12, 24 ,48,72 hours and 7 day after the surgery)