NL-OMON45069
Completed
Not Applicable
The role of regulatory T cells in the pathogenesis of sarcoidosis. - SARTREG
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- sarcoidosis
- Sponsor
- Erasmus MC, Universitair Medisch Centrum Rotterdam
- Enrollment
- 140
- Status
- Completed
- Last Updated
- last year
Overview
Brief Summary
No summary available.
Investigators
Eligibility Criteria
Inclusion Criteria
- •Sarcoidosis patients should have:
- •\- Newly diagnosed pulmonary sarcoidosis, established using the criteria of the World Association of Sarcoidosis and Other Granulomatous Disorders (WASOG)
- •\- Written informed consent
- •\- Age \> 18;Healthy controls should have:
- •\- Written informed consent;
- •\- Age \> 18\.;Tuberculosis patients should have:
- •\- Newly diagnosed tuberculosis with pulmonary caseating granulomas.
- •o Diagnosis is based on European Respiratory Society (ERS) guidelines.
- •\- Written informed consent;
- •\- Age \> 18\.
Exclusion Criteria
- •Sarcoidosis patients may not have:
- •\- Used oral corticosteroids, antimycotica or antibiotics 1 weeks prior to the collection of materials.
- •\- Used immunosuppressive medication or biologicals 3 months prior to the collection of materials.
- •\- A possible infection of the upper\- or lower respiratory tract 4 weeks prior to the collection of materials.
- •\- Other diseases which could influence pulmonary function, granuloma formation and/or the immune system, such as:
- •o Chronic obstructive pulmonary disorder (COPD) or astma in the medical history;
- •o Auto\-immune diseases such as systemic lupus erythematosus (SLE), rheumatoid arthritis (RA), myasthenia gravis or Goodpasture\*s syndrome;
- •o Malignancies;
- •o Human immunodeficiency virus (HIV);
- •o Pregnancy;
Outcomes
Primary Outcomes
Not specified
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