The role of regulatory T cells in the pathogenesis of sarcoidosis. - SARTREG

Erasmus MC, Universitair Medisch Centrum Rotterdam0 个研究点目标入组 140 人开始时间: 待定最近更新: 2024年7月8日

适应症

试验速览

暂无简介。

•Sarcoidosis patients should have:
•- Newly diagnosed pulmonary sarcoidosis, established using the criteria of the World Association of Sarcoidosis and Other Granulomatous Disorders (WASOG)
•- Written informed consent
•- Age > 18;Healthy controls should have:
•- Written informed consent;
•- Age > 18.;Tuberculosis patients should have:
•- Newly diagnosed tuberculosis with pulmonary caseating granulomas.
•o Diagnosis is based on European Respiratory Society (ERS) guidelines.
•- Written informed consent;
•- Age > 18.

•Sarcoidosis patients may not have:
•- Used oral corticosteroids, antimycotica or antibiotics 1 weeks prior to the collection of materials.
•- Used immunosuppressive medication or biologicals 3 months prior to the collection of materials.
•- A possible infection of the upper- or lower respiratory tract 4 weeks prior to the collection of materials.
•- Other diseases which could influence pulmonary function, granuloma formation and/or the immune system, such as:
•o Chronic obstructive pulmonary disorder (COPD) or astma in the medical history;
•o Auto-immune diseases such as systemic lupus erythematosus (SLE), rheumatoid arthritis (RA), myasthenia gravis or Goodpasture*s syndrome;
•o Malignancies;
•o Human immunodeficiency virus (HIV);
•o Pregnancy;
•o Allergies such as allergic rhinitis. ;Healthy controls may not have:
•- Sarcoidosis;
•- An abnormal spirometry with a FVC or FEV1 below the 80% of the predicted value;
•- A liaison with the coordinating or principal investigator, which could likely influence the decision to participate in this study voluntarily (in concordance with the WMO -article 5);
•- See exclusion criteria sarcoidosis patients. ;Tuberculosis patients may not have:
•- Sarcoidosis
•- See exclusion criteria sarcoidosis patients.

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