The Effect of New Zealand Blackcurrant (NZBC) Supplementation on Indices of Muscle Damage Following Strenuous Exercise
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 27
- 试验地点
- 2
- 主要终点
- Change from baseline in creatine kinase (CK) concentration at 72 hours post-exercise
研究概览
简要总结
The study aims to examine the effect of a New Zealand blackcurrant (NZBC) supplement on markers of muscle damage and recovery following strenuous resistance exercise. The investigation will compare responses between an experimental (NZBC capsule, 300 mg/day) and placebo (PLA capsule, 300 mg sugar) group. Participants will attend a screening session where they will consent to the study, complete a pre-activity medical questionnaire and have their height, weight and resting blood pressure measured. If the participants meet the inclusion criteria they will perform a familarisation session on the muscle strength assessment. Participants will be randomized to NZBC or placebo groups, and consume one capsule in the morning (between 6-10 am) for 12 days. This is a double-blinded study, which means that the participant and the study team will not know which group the participants are assigned to until the study is over. On day 8 participants will perform a strenuous bout of upper body resistance exercise on the isokinetic dynamometer (exercise device). Muscle strength and soreness, arm circumference, and elbow range of motion will be measured, and a fasted blood sample will be collected, before and 24, 48, 72 & 96 hours after the muscle fatigue protocol (on days 9, 10, 11 & 12). A marker of muscle damage (creatine kinase [CK] concentration) will be measured in the blood samples. Participants will also be asked to complete a 6-day dietary record, beginning on day 7 and ending on the final day of testing (day 12).
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Prevention
- 盲法
- Double (Participant, Investigator)
盲法说明
Coded, capsules
入排标准
- 年龄范围
- 18 Years 至 45 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Males and Females
- •18 - 45 years old
- •BMI: 19 - 29.9 kg/m2
- •Healthy: no active disease process that could interfere with endpoints measured as determined by medical history
排除标准
- •Smoking and tobacco use
- •Takes medication [excluding contraception]
- •BMI ≥ 30 kg/m2
- •Hypertensive (diastolic > 90 and/or systolic blood pressure > 140 mmHg)
- •History of musculoskeletal upper limb injuries
- •Performs regular resistance exercise (> 2 sessions per week)
- •Uses dietary supplements that could influence muscle recovery or function (e.g. protein supplements, antioxidants etc)
结局指标
主要结局
Change from baseline in creatine kinase (CK) concentration at 72 hours post-exercise
时间窗: At baseline (pre-exercise) and 72 hours post-exercise.
Serum biomarker for muscle damage
Change from baseline in creatine kinase (CK) concentration at 96 hours post-exercise
时间窗: At baseline (pre-exercise) and 96 hours post-exercise..
Serum biomarker for muscle damage
次要结局
- Change in joint range of motion (ROM) from baseline to 96 hours post-exercise(At baseline (pre-exercise) and post-exercise time points (at 24, 48, 72 and 96 hours respectively).)
- Change in maximum voluntary contraction (MVC) from baseline to 96 hours post-exercise(At baseline (pre-exercise) and post-exercise time points (at 0, 24, 48, 72 and 96 hours respectively).)
- Change in rating of Delayed Onset of Muscle Soreness (DOMS) from baseline to 96 hours post-exercise(At baseline (pre-exercise) and post-exercise time points (at 24, 48, 72 and 96 hours respectively).)
- Change in mid arm circumference (MAC) from baseline to 96 hours post-exercise(At baseline (pre-exercise) and post-exercise time points (at 24, 48, 72 and 96 hours respectively).)