A Study of Remternetug (LY3372993) in Early Alzheimer's Disease (TRAILRUNNER-ALZ 3)
- Registration Number
- NCT06653153
- Lead Sponsor
- Eli Lilly and Company
- Brief Summary
The purpose of this study is to measure the difference in time to developing or worsening memory, thinking, or functional problems due to Alzheimer's disease occurring in participants receiving study drug compared to placebo.
Participation could last up to 255 weeks including screening, a double-blind treatment period, and a double-blind observation period. In addition, eligible participants who receive placebo during the double-blind treatment period may choose to extend their study participation to receive open-label remternetug in an extension period.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- RECRUITING
- Sex
- All
- Target Recruitment
- 1200
- Have a phosphorylated tau (P-tau) result consistent with the presence of amyloid pathology.
- Have a reliable study partner and backup study partner familiar with overall function and behavior, such as day-to-day activities and cognitive abilities.
- Have adequate literacy, vision, and hearing for neuropsychological testing at screening.
- Have a Mini Mental Status Exam (MMSE) score consistent with no to minimal cognitive impairment.
- Have a Functional Activities Questionnaire (FAQ) score consistent with no to minimal functional impairment.
- If currently receiving medications as symptomatic treatment for AD, dose has been stable for at least 30 days before screening.
- Have dementia or significant other neurological disease that can affect cognition.
- Have current serious or unstable illnesses that in the investigator's opinion, could interfere with the analyses of the study.
- Have a history of cancer that, in the investigator's opinion, has a high risk of recurrence.
- Have a history of clinically significant multiple or severe drug allergies, or hypersensitivity reactions.
- Have a clinically important laboratory test result or other abnormality as determined by investigator, prior to randomization, that could be detrimental to the participant or could compromise the study.
- Have any contraindications for magnetic resonance imaging (MRI).
- Have a centrally read MRI that does not meets study entry criteria.
Prior or Current Therapies
- Have ever had prior treatment with a passive anti-amyloid immunotherapy.
- Have received active immunization against Aβ in any other study.
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Arm && Interventions
Group Intervention Description Remternetug Remternetug Remternetug administered subcutaneously (SC). Placebo Placebo Placebo administered SC.
- Primary Outcome Measures
Name Time Method Time to Clinically Meaningful Progression as Measured by Clinical Dementia Rate (CDR) Baseline to Time to Event up to Week 255 Time to clinically meaningful progression as measured by CDR. CDR is a clinician-rated scale that provides an overall assessment of the participant's stage and degree of impairment across the continuum of early Alzheimer's Disease (AD).
- Secondary Outcome Measures
Name Time Method Pharmacokinetics: Serum Concentrations of Remternetug Baseline through Week 255 PK: serum concentration of remternetug.
Change from Baseline in Clinical Dementia Rate Box Score (SB) Baseline, Week 255 Change from baseline in Clinical Dementia Rate Box Score (SB) scores range from 0 to 18, with higher scores indicative of more impairment.
Change from Baseline in Montreal Cognitive Assessment (MoCA) Baseline, Week 255 Change from baseline in Montreal Cognitive Assessment (MoCA). Total MoCA score is 0 to 30, with lower scores indicating greater level of impairment.
Change from Baseline in the Category Fluency - Language, Executive Function, Semantic Memory Baseline, Week 255 Change from baseline in the Category Fluency - Language, Executive Function, Semantic Memory. The total score reflects the sum of correct responses generated across all categories presented, with higher values indicating better performance.
Change from Baseline in the Continuous Paired Associate Learning (CPAL) Baseline, Week 255 Change from baseline in Continuous Paired Associate Learning (CPAL) - Visual episodic memory.
Change from Baseline in International Shopping List Test (ISLT) - Verbal Episodic Mem Baseline, Week 255 Change from baseline in the International Shopping List Test (ISLT) - verbal episodic memory.
Change from Baseline in International Daily Symbol Substitution Test-Medicines (iDSSTm) - Complex Attention Memory Baseline, Week 255 Change from baseline in the International Daily Symbol Substitution Test-Medicines (iDSSTm) - complex attention memory.
Change from Baseline in Cogstate Brief Battery (CBB) - Psychomotor Function, Attention, Learning and Working Memory Baseline, Week 255 Change from baseline in the Cogstate Brief Battery (CBB) - Psychomotor function, attention, learning, and working memory.
Change from Baseline in Cognitive Function Index (CFI) Baseline, Week 255 Change from baseline in the Cognitive Function Index (CFI).
Change from Baseline in Mild Behavioral Impairment Checklist (MBI-C) Baseline, Week 255 Change from baseline in the Mild Behavioral Impairment Checklist (MBI-C) The MBI-C total score range is 0 to 102, with higher scores indicating greater impairment.
Change from Baseline in Alzheimer's Disease Cooperative Study (ADCS) Activities of Daily Living - Prevention Instrument (ADCS-ADL-PI) Baseline, Week 255 Change from baseline in the Activities of Daily Living - Prevention Instrument total scores range from 0 to 54, with higher scores indicating better performance.
Number of Participants with Treatment Emergent Anti-Drug Antibodies (TE-ADAs) Baseline through Week 255 Number of participants with treatment emergent anti-drug antibodies (TE-ADAs).
Trial Locations
- Locations (297)
Hanyang University Seoul Hospital
🇰🇷Seoul, Seoul-teukbyeolsi [Seoul], Korea, Republic of
Konkuk University Medical Center
🇰🇷Seoul, Seoul-teukbyeolsi [Seoul], Korea, Republic of
Asan Medical Center
🇰🇷Seoul, Seoul-teukbyeolsi [Seoul], Korea, Republic of
Samsung Medical Center
🇰🇷Seoul, Seoul-teukbyeolsi [Seoul], Korea, Republic of
The Catholic Univ. of Korea Seoul St. Mary's Hospital
🇰🇷Seoul, Seoul-teukbyeolsi [Seoul], Korea, Republic of
Kyungpook National University Chilgok Hospital
🇰🇷Deagu, Taegu-Kwangyǒkshi, Korea, Republic of
Health Pharma Professional Research S.A. de C.V:
🇲🇽Ciudad de México, Distrito Federal, Mexico
Grupo Medico Camino Sc
🇲🇽Mexico City, Distrito Federal, Mexico
Boca Clinical Trials Mexico S.C.
🇲🇽Guadajalara, Jalisco, Mexico
Centro de Investigación Clínica y Medicina Traslacional (CIMeT)
🇲🇽Guadalajara, Jalisco, Mexico
Avix Investigación Clinica, S.C.
🇲🇽Monterrey, Nuevo León, Mexico
Hospital Universitario "Dr. Jose Eleuterio Gonzalez"
🇲🇽Monterrey, Nuevo León, Mexico
Centro de Investigacion Clinica de Oaxaca
🇲🇽Oaxaca de Juarez, Oaxaca, Mexico
Medical Care and Research SA de CV
🇲🇽Merida, Yucatán, Mexico
San Peregrino Unidad de Investigación
🇲🇽Aguascalientes, Mexico
Investigacion y Biomedicina de Chihuahua
🇲🇽Chihuahua, Mexico
SCB Research Center
🇵🇷Bayamon, Puerto Rico
Caribbean Medical Research Center
🇵🇷San Juan, Puerto Rico
INSPIRA Clinical Research
🇵🇷San Juan, Puerto Rico
Instituto De Neurologia Dra. Ivonne Fraga
🇵🇷San Juan, Puerto Rico
Hospital Victoria Eugenia
🇪🇸Seville, Andalucía, Spain
Barcelonabeta Brain Research Center
🇪🇸Barcelona, Barcelona [Barcelona], Spain
Fundació ACE
🇪🇸Barcelona, Barcelona [Barcelona], Spain
Hospital Clínic de Barcelona
🇪🇸Barcelona, Catalunya [Cataluña], Spain
Hospital de la Santa Creu i Sant Pau
🇪🇸Barcelona, Catalunya [Cataluña], Spain
Hospital Universitario Quironsalud Madrid
🇪🇸Pozuelo de Alarcon, Madrid, Spain
Policlinica Gipuzkoa
🇪🇸San Sebastián, País Vasco, Spain
Changhua Christian Hospital
🇨🇳Changhua County, Changhua, Taiwan
Far Eastern Memorial Hospital
🇨🇳New Taipei City, New Taipei, Taiwan
Cardinal Tien Hospital
🇨🇳New Taipei City, New Taipei, Taiwan
Chang Gung Memorial Hospital at Kaohsiung
🇨🇳Kaohsiung Niao Sung Dist, Kaohsiung, Taiwan
New Taipei Municipal TuCheng Hospital
🇨🇳New Taipei City, New Taipei, Taiwan
National Taiwan University Hospital Yun-Lin Branch Dou-Liou Region
🇨🇳Douliu City, Yunlin, Taiwan
Taipei Medical University Shuang Ho Hospital
🇨🇳New Taipei, Taiwan
China Medical University Hospital
🇨🇳Taichung, Taiwan
Taichung Veterans General Hospital
🇨🇳Taichung, Taiwan
National Cheng Kung University Hospital
🇨🇳Tainan, Taiwan
National Taiwan University Hospital
🇨🇳Taipei, Taiwan
Taipei Veterans General Hospital
🇨🇳Taipei, Taiwan
Chang Gung Medical Foundation-Linkou Branch
🇨🇳Taoyuan, Taiwan
ReMind UK
🇬🇧Bath, Bath And North East Somerset, United Kingdom
Homecroft Surgery
🇬🇧Redruth, Cornwall, United Kingdom
Roborough Surgery
🇬🇧Plymouth, Devon, United Kingdom
Scottish Brain Sciences
🇬🇧Edinburgh, Edinburgh, City Of, United Kingdom
Abbeywell Surgery
🇬🇧Romsey, England, United Kingdom
St Margaret's Hospital
🇬🇧Epping, Essex, United Kingdom
NeuroClin
🇬🇧Motherwell, Great Britain, United Kingdom
Moorgreen Hospital
🇬🇧Southampton, Hampshire, United Kingdom
Layton Medical Centre
🇬🇧Blackpool, Lancashire, United Kingdom
St Pancras Clinical Research
🇬🇧London, London, City Of, United Kingdom
Warneford Hospital
🇬🇧Oxford, Oxfordshire, United Kingdom
Cheadle Community Hospital
🇬🇧Cheadle, Staffordshire, United Kingdom
Marine Lake Medical Practice
🇬🇧West Kirby, Wirral, United Kingdom
Re:Cognition Health - Birmingham
🇬🇧Birmingham, United Kingdom
NIHR Manchester Clinical Research Facility
🇬🇧Manchester, United Kingdom
Parkway Medical Center
🇺🇸Birmingham, Alabama, United States
MD First Research - Chandler
🇺🇸Chandler, Arizona, United States
Care Access - 801 South Power Road, Mesa
🇺🇸Mesa, Arizona, United States
Banner Alzheimer's Institute
🇺🇸Phoenix, Arizona, United States
Banner Alzheimer's Institute Tucson
🇺🇸Tucson, Arizona, United States
Neuro-Pain Medical Center
🇺🇸Fresno, California, United States
Care Access - Huntington Beach
🇺🇸Huntington Beach, California, United States
Inglewood Clinical
🇺🇸Inglewood, California, United States
Irvine Clinical Research
🇺🇸Irvine, California, United States
Healthy Brain Clinic
🇺🇸Long Beach, California, United States
Riverside Clinical
🇺🇸Riverside, California, United States
Clinical Trials Research
🇺🇸Sacramento, California, United States
Artemis Institute for Clinical Research
🇺🇸San Diego, California, United States
ClinCloud
🇺🇸Melbourne, Florida, United States
Sharp Neurocognitive Research Center
🇺🇸San Diego, California, United States
Ray Dolby Brain Health Center
🇺🇸San Francisco, California, United States
The Neuron Clinic - San Marcos
🇺🇸San Marcos, California, United States
Syrentis Clinical Research
🇺🇸Santa Ana, California, United States
Providence Medical Foundation
🇺🇸Santa Rosa, California, United States
California Neuroscience Research, LLC
🇺🇸Sherman Oaks, California, United States
Care Access - Aurora
🇺🇸Aurora, Colorado, United States
Mountain Neurological Research Center
🇺🇸Basalt, Colorado, United States
Alpine Clinical Research Center
🇺🇸Boulder, Colorado, United States
CenExel Rocky Mountain Clinical Research
🇺🇸Englewood, Colorado, United States
Invicro
🇺🇸New Haven, Connecticut, United States
Ki Health Partners, LLc, dba New England Institute for Clinical Research
🇺🇸Stamford, Connecticut, United States
JEM Research Institute
🇺🇸Atlantis, Florida, United States
VIN-Julie Schwartzbard
🇺🇸Aventura, Florida, United States
Bradenton Research Center, Inc.
🇺🇸Bradenton, Florida, United States
K2 Medical Research WINTER GARDEN
🇺🇸Clermont, Florida, United States
TecTum Research
🇺🇸Davie, Florida, United States
Brain Matters Research
🇺🇸Delray Beach, Florida, United States
Neuropsychiatric Research Center of Southwest Florida
🇺🇸Fort Myers, Florida, United States
Indago Research & Health Center, Inc
🇺🇸Hialeah, Florida, United States
K2 MEDICAL Research THE VILLAGES
🇺🇸Lady Lake, Florida, United States
K2 Medical Research ORLANDO
🇺🇸Maitland, Florida, United States
Merritt Island Medical Research, LLC
🇺🇸Merritt Island, Florida, United States
VIN-Andrew Lerman
🇺🇸Miami, Florida, United States
New Age Medical Research Corporation
🇺🇸Miami, Florida, United States
Adult Medicine of Lake County, Inc.
🇺🇸Mount Dora, Florida, United States
Aqualane Clinical Research
🇺🇸Naples, Florida, United States
Suncoast Clinical Research, Inc.
🇺🇸New Port Richey, Florida, United States
Renstar Medical Research
🇺🇸Ocala, Florida, United States
Charter Research - Winter Park
🇺🇸Orlando, Florida, United States
AdventHealth Orlando
🇺🇸Orlando, Florida, United States
Emerald Coast Neurology - Airport Boulevard
🇺🇸Pensacola, Florida, United States
Axiom Brain Health LLC
🇺🇸Tampa, Florida, United States
Progressive Medical Research
🇺🇸Port Orange, Florida, United States
Care Access - Tampa
🇺🇸Tampa, Florida, United States
Charter Research - Lady Lake
🇺🇸The Villages, Florida, United States
Alzheimer's Research and Treatment Center
🇺🇸Wellington, Florida, United States
Stedman Clinical Trials
🇺🇸Tampa, Florida, United States
Palm Beach Neurology
🇺🇸West Palm Beach, Florida, United States
Conquest Research
🇺🇸Winter Park, Florida, United States
Columbus Memory Center, LLC
🇺🇸Columbus, Georgia, United States
Care Access - Decatur
🇺🇸Decatur, Georgia, United States
Center for Advanced Research & Education
🇺🇸Gainesville, Georgia, United States
North Georgia Clinical Research
🇺🇸Woodstock, Georgia, United States
Northwest Clinical Trials
🇺🇸Boise, Idaho, United States
Re:Cognition Health - Chicago
🇺🇸Chicago, Illinois, United States
Great Lakes Clinical Trials - Andersonville
🇺🇸Chicago, Illinois, United States
Care Access - Chicago
🇺🇸Chicago, Illinois, United States
Alexian Brothers Medical Center
🇺🇸Elk Grove Village, Illinois, United States
Care Access - South Indianapolis
🇺🇸Indianapolis, Indiana, United States
Josephson Wallack Munshower Neurology, PC
🇺🇸Indianapolis, Indiana, United States
Cedar Valley Medical Specialists
🇺🇸Waterloo, Iowa, United States
Cotton O'Neil Clinical Research Center
🇺🇸Topeka, Kansas, United States
Care Access - Lake Charles (Bayou Pines)
🇺🇸Lake Charles, Louisiana, United States
Tandem Clinical Research
🇺🇸Marrero, Louisiana, United States
Acadia Hospital
🇺🇸Bangor, Maine, United States
Care Access - Baltimore
🇺🇸Baltimore, Maryland, United States
Copley Clinical
🇺🇸Boston, Massachusetts, United States
Boston Clinical Trials
🇺🇸Boston, Massachusetts, United States
Boston Center for Memory
🇺🇸Newton, Massachusetts, United States
Care Access - Quincy
🇺🇸Quincy, Massachusetts, United States
MedVadis Research Corporation
🇺🇸Waltham, Massachusetts, United States
Adams Clinical
🇺🇸Watertown, Massachusetts, United States
Revival Research Institute, LLC
🇺🇸Dearborn, Michigan, United States
QUEST Research Institute
🇺🇸Farmington Hills, Michigan, United States
HealthPartners Neuroscience Center
🇺🇸Saint Paul, Minnesota, United States
Private Practice - Dr. Ronald Louis Schwartz
🇺🇸Hattiesburg, Mississippi, United States
Citizens Memorial Hospital District
🇺🇸Bolivar, Missouri, United States
Clinical Research Professionals
🇺🇸Chesterfield, Missouri, United States
University Of Nebraska Medical Center
🇺🇸Omaha, Nebraska, United States
Vector Clinical Trials
🇺🇸Las Vegas, Nevada, United States
Care Access - Hoboken
🇺🇸Hoboken, New Jersey, United States
The Cognitive and Research Center of New Jersey - Ridgewood
🇺🇸Ridgewood, New Jersey, United States
The Cognitive and Research Center of New Jersey
🇺🇸Springfield, New Jersey, United States
Advanced Memory Research Institute of New Jersey
🇺🇸Toms River, New Jersey, United States
IMA Clinical Research
🇺🇸Albuquerque, New Mexico, United States
Care Access - Charlotte
🇺🇸Charlotte, North Carolina, United States
Medication Management
🇺🇸Greensboro, North Carolina, United States
Monroe Biomedical Research
🇺🇸Monroe, North Carolina, United States
Care Access - Lima
🇺🇸Lima, Ohio, United States
North Star Medical Research
🇺🇸Middleburg Heights, Ohio, United States
Summit Headlands
🇺🇸Portland, Oregon, United States
Clinical Research of Philadelphia
🇺🇸Philadelphia, Pennsylvania, United States
Keystone Clinical Studies
🇺🇸Plymouth Meeting, Pennsylvania, United States
Rhode Island Mood & Memory Research Institute
🇺🇸East Providence, Rhode Island, United States
Butler Hospital
🇺🇸Providence, Rhode Island, United States
Tribe Clinical Research, LLC
🇺🇸Greenville, South Carolina, United States
Palmetto Clinical Research
🇺🇸Summerville, South Carolina, United States
Neurology Clinic, P.C.
🇺🇸Cordova, Tennessee, United States
Genesis Neuroscience Clinic
🇺🇸Knoxville, Tennessee, United States
Senior Adults Specialty Research
🇺🇸Austin, Texas, United States
Gadolin Research
🇺🇸Beaumont, Texas, United States
Kerwin Medical Center - Oak Cliff
🇺🇸Dallas, Texas, United States
Kerwin Medical Center
🇺🇸Dallas, Texas, United States
Care Access - Georgetown
🇺🇸Georgetown, Texas, United States
Care Access - Houston
🇺🇸Houston, Texas, United States
The University of Texas Health Science Center at Houston
🇺🇸Houston, Texas, United States
Next Level Urgent Care
🇺🇸Houston, Texas, United States
El Faro Health and Therapeutics
🇺🇸Rio Grande City, Texas, United States
Central Texas Neurology Consultants, PA
🇺🇸Round Rock, Texas, United States
IMA Clinical Research San Antonio
🇺🇸San Antonio, Texas, United States
Consano Clinical Research, LLC
🇺🇸Shavano Park, Texas, United States
Care Access - Arlington
🇺🇸Arlington, Virginia, United States
Re:Cognition Health
🇺🇸Fairfax, Virginia, United States
Eastern Virginia Medical School (EVMS) Medical Group
🇺🇸Norfolk, Virginia, United States
Northwest Clinical Research Center
🇺🇸Bellevue, Washington, United States
Rainier Clinical Research Center
🇺🇸Renton, Washington, United States
Fundación Respirar
🇦🇷Ciudad Autónoma de Buenos Aires, Buenos Aires, Argentina
IDIM - Instituto de Investigaciones Metabólicas
🇦🇷Ciudad de Buenos Aires, Buenos Aires, Argentina
Hospital Italiano de Buenos Aires
🇦🇷ABB, Ciudad Autónoma De Buenos Aires, Argentina
Stat Research S.A.
🇦🇷Buenos Aires, Ciudad Autónoma De Buenos Aires, Argentina
Mautalen Salud e Investigación
🇦🇷Buenos Aires, Ciudad Autónoma De Buenos Aires, Argentina
Fundacion Estudios Clinicos
🇦🇷Rosario, Santa Fe, Argentina
Instituto de Investigaciones Clinicas Rosario
🇦🇷Rosario, Santa Fe, Argentina
Centro de Investigaciones Médicas Tucuman
🇦🇷SAN M. DE Tucuman, Tucumán, Argentina
Instituto de Neurología Cognitiva (INECO)
🇦🇷Buenos Aires, Argentina
Instituto Médico Especializado (IME)
🇦🇷Buenos Aires, Argentina
CIPREC
🇦🇷Buenos Aires, Argentina
Fundación para la Lucha contra las Enfermedades Neurológicas de la Infancia (FLENI)
🇦🇷Buenos Aires, Argentina
Centro de Educación Médica e Investigaciones clínicas "Dr. Norberto Quirno" (CEMIC)
🇦🇷Buenos Aires, Argentina
Instituto Argentino de Investigación Neurológica (IADIN)
🇦🇷Ciudad Autónoma de Buenos Aires, Argentina
Centro de Investigaciones Metabólicas (CINME)
🇦🇷Ciudad Autónoma de Buenos Aires, Argentina
Centro Médico Arsema
🇦🇷Ciudad Autónoma de Buenos Aires, Argentina
CEN Centro Especializado en Neurociencias
🇦🇷Córdoba, Argentina
Instituto Kremer
🇦🇷Córdoba, Argentina
Fundacion Scherbovsky
🇦🇷Mendoza, Argentina
Centro de Diagnóstico y Rehabilitación (CEDIR)
🇦🇷Santa Fe, Argentina
Emeritus Research
🇦🇺Camberwell, Victoria, Australia
GenesisCare - Maitland
🇦🇺East Maitland, New South Wales, Australia
Southern Neurology
🇦🇺Kogarah, New South Wales, Australia
KARA Institute for Neurological Diseases
🇦🇺Macquarie Park, New South Wales, Australia
St Vincent's Hospital
🇦🇺Sydney, New South Wales, Australia
USC Clinical Trials Sunshine Coast
🇦🇺Birtinya, Queensland, Australia
The University of Queensland
🇦🇺Herston, Queensland, Australia
Ipswich Hospital
🇦🇺Ipswich, Queensland, Australia
USC Clinical Trials Brisbane (South Bank)
🇦🇺South Brisbane, Queensland, Australia
Fusion Clinical Research
🇦🇺Norwood, South Australia, Australia
The Queen Elizabeth Hospital
🇦🇺Woodville, South Australia, Australia
Box Hill Hospital
🇦🇺Box Hill, Victoria, Australia
Austin Health
🇦🇺Ivanhoe, Victoria, Australia
HammondCare
🇦🇺Malvern, Victoria, Australia
The Royal Melbourne Hospital
🇦🇺Parkville, Victoria, Australia
Alzheimer's Research Australia
🇦🇺Nedlands, Western Australia, Australia
OCT Research ULC
🇨🇦Kelowna, British Columbia, Canada
The Medical Arts Health Research Group - West Vancouver
🇨🇦West Vancouver, British Columbia, Canada
Ottawa Memory Clinic
🇨🇦Ottawa, Ontario, Canada
Kawartha Centre - Redefining Healthy Aging
🇨🇦Peterborough, Ontario, Canada
Bluewater Clinical Research Group Inc.
🇨🇦Sarnia, Ontario, Canada
Toronto Memory Program
🇨🇦Toronto, Ontario, Canada
Sunnybrook Research Institute
🇨🇦Toronto, Ontario, Canada
Baycrest Health Sciences
🇨🇦Toronto, Ontario, Canada
Ecogene-21 - Cmas
🇨🇦Chicoutimi, Quebec, Canada
MoCA Research and Innovation Inc.
🇨🇦Greenfield Park, Quebec, Canada
Alpha Recherche Clinique - Lévis
🇨🇦Lévis, Quebec, Canada
Genge Partners
🇨🇦Montreal, Quebec, Canada
Clinique Mémoire de Montréal
🇨🇦Montréal, Quebec, Canada
Q&T Research Sherbrooke Inc.
🇨🇦Sherbrooke, Quebec, Canada
Diex Recherche Victoriaville
🇨🇦Victoriaville, Quebec, Canada
Alpha Recherche Clinique
🇨🇦Quebec, Canada
Anhui Provincial Hospital
🇨🇳Hefei, Anhui, China
ALPHA Recherche Clinique
🇨🇦Quebec, Canada
Beijing Tiantan Hospital Affiliated to Capital Medical University
🇨🇳Beijing, Beijing, China
Beijing Anding Hospital - Affiliated Capital University of Medical Science
🇨🇳Beijing, Beijing, China
Guangdong Provincial People's Hospital
🇨🇳Guangzhou, Guangdong, China
Guangzhou First People's Hospital
🇨🇳Guangzhou, Guangdong, China
Guangzhou Medical University 2nd Hospital
🇨🇳Guangzhou, Guangdong, China
Zhujiang Hospital
🇨🇳Guangzhou, Guangdong, China
The First Hospital of Hebei Medical University
🇨🇳Shijiazhuang, Hebei, China
The First Affiliated Hospital of Henan University of Science &Technology
🇨🇳Luoyang, Henan, China
Xiangya Hospital Central South University
🇨🇳Changsha, Hunan, China
Nanjing Brain Hospital
🇨🇳Nanjing, Jiangsu, China
Sir Run Run Hospital of Nanjing Medical University
🇨🇳Nanjing, Jiangsu, China
The Second Affiliated Hospital of Soochow University
🇨🇳Suzhou, Jiangsu, China
The Affiliated Hospital of Xuzhou Medical College
🇨🇳Xuzhou, Jiangsu, China
Xuzhou Central Hospital
🇨🇳Xuzhou, Jiangsu, China
The Second Affiliated Hospital of Nanchang University
🇨🇳Nanchang, Jiangxi, China
The First Affiliated Hospital of Nanchang University
🇨🇳Nanchang, Jiangxi, China
The First Hospital of Jilin University
🇨🇳Changchun, Jilin, China
The First Affiliated Hospital of Xi'an Medical University
🇨🇳Xi'an, Shaanxi, China
Xianyang Hospital of Yan'an University
🇨🇳Xianyang, Shaanxi, China
Shaanxi provincial people's hospital
🇨🇳Xian, Shaanxi, China
Jinan Central Hospital
🇨🇳Jinan, Shandong, China
Shanghai Sixth People's Hospital
🇨🇳Shanghai, Shanghai, China
Huashan Hospital, Fudan University
🇨🇳Shanghai, Shanghai, China
Renji Hospital Shanghai Jiao Tong University School of Medicine
🇨🇳Shanghai, Shanghai, China
Pudong New Area People's Hospital Shanghai
🇨🇳Shanghai, Shanghai, China
Sichuan Provincial People's Hospital
🇨🇳Chengdu, Sichuan, China
Zigong First People's Hospital
🇨🇳Zigong, Sichuan, China
Tianjin Medical University General Hospital
🇨🇳Tianjin, Tianjin, China
National Center for Geriatrics and Gerontology
🇯🇵Obu, Aichi, Japan
Saiseikai Imabari Hospital
🇯🇵Imabari, Ehime, Japan
Hyogo Prefectural Harima-Himeji General Medical Center
🇯🇵Himeji, Hyogo, Japan
Kobe University Hospital
🇯🇵Kobe, Hyogo, Japan
Kawashima Neurology Clinic
🇯🇵Fujisawa, Kanagawa, Japan
Medical Corporation Heishinkai OCROM Clinic
🇯🇵Suita-shi, Osaka, Japan
Takatsuki Hospital
🇯🇵Takatsuki-shi, Osaka, Japan
Wako Hospital
🇯🇵Wako, Saitama, Japan
The University of Tokyo Hospital
🇯🇵Bunkyo-ku, Tokyo, Japan
Medical Corporation Chiseikai Tokyo Center Clinic
🇯🇵Chuo-ku, Tokyo, Japan
Tokyo-Eki Center-building Clinic
🇯🇵Chuo-ku, Tokyo, Japan
Fukuwa Clinic
🇯🇵Chuo-ku, Tokyo, Japan
Tokyo Asbo Clinic
🇯🇵Chuo-ku, Tokyo, Japan
P-One Clinic
🇯🇵Hachioji, Tokyo, Japan
Tokyo Metropolitan Geriatric Hospital
🇯🇵Itabashi, Tokyo, Japan
Showa General Hospital
🇯🇵Kodaira, Tokyo, Japan
Sakurazaka Clinic SophyAnce
🇯🇵Minato-ku, Tokyo, Japan
Kanto Central Hospital
🇯🇵Setagaya-ku, Tokyo, Japan
Clinical Research Hospital Tokyo
🇯🇵Shinjuku-ku, Tokyo, Japan
Heishinkai Medical Group ToCROM Clinic
🇯🇵Shinjuku-ku, Tokyo, Japan
Higashi Shinjuku Clinic
🇯🇵Shinjuku-ku, Tokyo, Japan
Samoncho Clinic
🇯🇵Shinjuku, Tokyo, Japan
Tachikawa Hospital
🇯🇵Tachikawa, Tokyo, Japan
UNB Sumiyoshi Jinjamae Clinic
🇯🇵Fukuoka, Japan
Boocs Clinic Fukuoka
🇯🇵Fukuoka, Japan
Tatsuoka Neurology Clinic
🇯🇵Kyoto, Japan
Iwata Neurosurgery Clinic
🇯🇵Osaka, Japan
Chungbuk National University Hospital
🇰🇷Cheongju-si, Chungcheongbuk-do [Chungbuk], Korea, Republic of
Inha University Hospital
🇰🇷Incheon, Incheon-gwangyeoksi [Incheon], Korea, Republic of
Gachon University Gil Medical Center
🇰🇷Namdong-gu, Incheon-gwangyeoksi [Incheon], Korea, Republic of
Jeju National University Hospital
🇰🇷Jeju-si, Jeju-teukbyeoljachido [Jeju], Korea, Republic of
Wonju Severance Christian Hospital
🇰🇷Wonju, Kang-won-do, Korea, Republic of
Chonnam National University Hospital
🇰🇷Gwangju-si, Kwangju-Kwangyǒkshi, Korea, Republic of
Seoul National University Bundang Hospital
🇰🇷Seongnam, Kyǒnggi-do, Korea, Republic of
Ajou University Hospital
🇰🇷Suwon, Kyǒnggi-do, Korea, Republic of
Pusan National University Hospital
🇰🇷Busan, Pusan-Kwangyǒkshi, Korea, Republic of
Gangnam Severance Hospital, Yonsei University Health System
🇰🇷Gangnam-gu, Seoul-teukbyeolsi [Seoul], Korea, Republic of
Ewha Womans University Seoul Hospital
🇰🇷Gangseo-gu, Seoul-teukbyeolsi [Seoul], Korea, Republic of
Seoul National University Hospital
🇰🇷Seoul, Seoul-teukbyeolsi [Seoul], Korea, Republic of