Effects of Breathing and Leg Muscle Training in Patients with Heart Failure

Not Applicable

• Conditions: Heart failure

• Registration Number: RBR-244m9ng
• Lead Sponsor: Instituto Nobre de Cardiologia

Brief Summary

Introduction: Current guidelines recommend exercise and physical activity as adjunctive therapies to pharmacological treatment, including inspiratory muscle training (IMT) and neuromuscular training. Objective: To evaluate the impact of inspiratory and peripheral muscle training on respiratory and peripheral muscle strength, pulmonary function and functional capacity in patients with heart failure. Methods: This is a randomized controlled trial. Participants were randomized by lottery into four groups: GROUP 1 (Control), GROUP 2 (IMT - Inspiratory Muscle Training), GROUP 3 (PMT - Peripheral Muscle Training) or GROUP 4 (IMT + PMT). Results: With regard to muscle strength, we noticed that the group that underwent inspiratory muscle treatment together with peripheral muscle training obtained a significant increase in both MIP (74 ± 15 at baseline versus 91 ± 16 at hospital discharge, p<0.01) and MEP (92 ± 19 at baseline versus 102 ± 18 at hospital discharge, p<0.01). With regard to lung function, the groups that underwent inspiratory muscle training, peripheral muscle training or inspiratory muscle training with peripheral muscle training showed an improvement in vital capacity (VC) when comparing baseline with discharge (p<0.01). With regard to peripheral muscle strength, there was no statistically significant difference in any group compared to the first assessment. However, with regard to the distance covered, we noticed that the group that underwent inspiratory muscle treatment with peripheral muscle training achieved a significant increase in the 6MWT (438 ± 47 at baseline versus 471 ± 51 at discharge). Conclusion: There was evidence of an improvement in respiratory strength, lung function, peripheral strength and an increase in the distance covered in the 6MWT. However, the group that performed inspiratory muscle training combined with peripheral muscle training showed a statistically significant improvement.

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Completion: 2017-12-31
• Study Start: 2023-10-16
• Last Update Posted: 13 November 2023

Recruitment & Eligibility

• Status: Recruitment completed
• Sex: Not specified
• Target Recruitment: Not specified

Inclusion Criteria

Individuals of both sexes with heart failure (CHF); Functional class III and IV according to the New York Heart Association classification; aged over 18 years.

Exclusion Criteria

Patients with unstable ventricular arrhythmia; Peripheral vascular disease; Acute respiratory disease; Unstable angina; Aortic stenosis; Current smoking; Chronic kidney disease or undergoing hemodialysis; Fever and/or infectious disease; Malignant neoplasms; Cognitive impairment; Failure to perform the proposed techniques; Failure to sign the consent form.

Study & Design

• Study Type: Intervention
• Study Design: Not specified