Evaluation of effects of lignocaine infusion on postoperative pain relief for abdominal surgery.

Not yet recruiting

• Conditions: Disorders of gallbladder, biliarytract and pancreas in diseases classified elsewhere, (2) ICD-10 Condition: K566||Other and unspecified intestinal obstruction,

• Registration Number: CTRI/2020/04/024743
• Lead Sponsor: NA

Brief Summary

The pain anddiscomfort after major surgical procedures are well known. Despite advances inknowledge of pathophysiology, pharmacology of analgesics and the development ofmore effective techniques for post-operative pain control, many patientscontinue to experience appreciable discomfort. Patients undergoing majorabdominal operations experience severe pain and marked respiratory impairmentbecause of pain in the postoperative period.4

We areincreasingly becoming aware of the risks associated with the use of invasivetechniques in the treatment of postoperative pain. Epidural infusions arecertainly more expensive, cumbersome and invasive than intravenous infusions.Furthermore, modern thromboprophylaxis practice with low molecular weightheparins often preclude the use of continuous epidural therapy because ofconcern over risk of epidural bleeding and hematoma. It is becomingincreasingly apparent that local anaesthetic such as lignocaine in the systemiccirculation can profoundly alter post-operative pain.  Intravenous lignocaine in the therapeuticdose as used for cardiac arrhythmias treatment, have been shown to reducepostoperative pain scores and opioid consumption; the presence of these drugsin the circulation for only a few hours can suppress pain for days after surgery.Therefore, intravenous lignocaine is appealing as a simple and inexpensivemethod to gain the same benefits as more invasive and costly techniques.

Detailed Description

Not available

Study Timeline

• Last Update Posted: 2020-04-17
• Study Start: 2020-04-20

Recruitment & Eligibility

• Status: Not Yet Recruiting
• Sex: All
• Target Recruitment: 30

Inclusion Criteria

Patients in age groups 18- 70 Healthy patients belonging to ASA PS I and II Patients undergoing elective upper abdominal surgery.

Exclusion Criteria

Inability to understand preoperative instructions regarding use of PCA pump or pain score Planned elective postoperative mechanical ventilation Patients known to be on anti-arrhythmic drug therapy History of COPD, cardiac, hepatic, renal or nervous system disorder Known allergy to lignocaine.

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
TOTAL MORPHINE CONSUMPTION at the end of 2nd, 6th, 12th, 24th and 36th postoperative hour.	Immediate postoperative period | 36 hours after surgery
TIME INTERVAL between skin closure and first morphine PCA request.	Immediate postoperative period | 36 hours after surgery

Secondary Outcome Measures

Name	Time	Method
PAIN SCORE (NRS) at rest, on deep inspiration, cough and movement (side to side or leg raising) at the end of 2nd, 6th, 12th, 24th and 36th postoperative hour.	Any complaints of –perioral numbness, light headedness.

Trial Locations

Locations (1)

Kasturba Hospital,Manipal; 🇮🇳 Udupi, KARNATAKA, India

Kasturba Hospital,Manipal

🇮🇳Udupi, KARNATAKA, India

Dr Lokvendra Singh Budania

Principal investigator

9901628947

drbudania@gmail.com