The Effect of Exercises on Physiological Changes and Clinical Symptoms in Allergic Rhinitis Patients
- Conditions
- Allergic Rhinitis
- Interventions
- Other: Aerobic exercise with Vit. COther: Aerobic exerciseOther: No exercise
- Registration Number
- NCT02123914
- Lead Sponsor
- Chulalongkorn University
- Brief Summary
1. Moderate exercise training decrease cytokine response and rhinitis symptoms in patients with allergic rhinitis
2. Moderate exercise training combined with vitamin C supplementation decrease cytokine response and rhinitis symptoms in patients with allergic rhinitis
3. Moderate exercise training combined with vitamin C supplementation has more beneficial effects than moderate exercise training alone for decreasing cytokine response and rhinitis symptoms in patients with allergic rhinitis
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 27
The inclusion criteria included patients with allergic rhinitis who had a clinical history of persistent rhinitis, and had positive skin prick test (wheal diameter ≥ 3 mm) to house dust mite (D. pteronyssinus).
Subjects with known asthma, chronic rhinosinusitis, hypertension or cardiovascular diseases were excluded.
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- FACTORIAL
- Arm && Interventions
Group Intervention Description Aerobic exercise with Vit. C & Aerobic exercise Aerobic exercise - exercise without vit. c supplement & no exercise Aerobic exercise with Vit. C - Aerobic exercise with Vit. C & Aerobic exercise Aerobic exercise with Vit. C - exercise without vit. c supplement & no exercise No exercise -
- Primary Outcome Measures
Name Time Method Changes from baseline in rhinitis symptoms Baseline, week 8 Nasal symptoms will be assessed using a rhinitis symptom score questionnaire. The subjects will be asked to score symptoms of persistent allergic rhinitis; nasal congestion, itching, sneezing, and rhinorrhea before and after each exercise protocol. The score ranged from 0 to 3 points (0 = none, 1 = mild, 2 = moderate, 3 = severe).
Changes from baseline in cytokine baseline, week 8 The cytokines IL-2, IL-4, and IL-13 in blood and nasal secretion will be determined by using the flow cytometry technique (Scavuzzo MC. et al., 2003). Data will be acquired using a flow cytometer (BD FACSCalibur Flow Cytometer, USA) and analyzed by FlowcytomixTM Pro software (eBioscience, USA.).
- Secondary Outcome Measures
Name Time Method Changes from baseline in pulmonary function Baseline, Week 8 Pulmonary function (FVC and FEV1) will be conducted on all subjects using a calibrated computerized pneumotachograph spirometer (Spirotouch; Burdick, Inc., Deerfield, Wisconsin USA.) according to American Thoracic Society (ATS) recommendations (Laszlo G., 2006).
Changes from baseline in peak nasal inspiratory flow Baseline, Week 8 Peak nasal inspiratory flow (PNIF) will be measured using a peak nasal inspiratory flow meter (Clement Clark International model IN-CHECK ORAL, UK.) attached to an anesthesia mask. During the procedure, the subjects placed a mask over the nose and mouth and inspired forcefully through the nose, with lips tightly closed. PNIF will be measured before and after exercise.
Changes from baseline in cardiorespiratory fitness (VO2max) Baseline, Week 8 VO2max will be performed using bruce treadmill protocol. Subjects will be asked to run on a treadmill (Landice, USA) in which the grade and intensity will be increased every 3 minutes until exhaustion.
Changes from baseline in nasal blood flow Baseline, week 8 Nasal mucosa blood flow will be measured by laser doppler flowmetry (DRT4 moor instrument, UK.). A side delivery endoscopic probe with flexible nylon sleeve with a diameter of 1.34 mm was placed on the anterior surface of the nose. The nasal blood flow values before and after exercise in each protocol will be then measured.
Trial Locations
- Locations (1)
Faculty of Sports Science, Chulalongkorn University
🇹🇭Patumwan, Bangkok, Thailand