Effects of exercise training on obstructive and central sleep apnea in coronary artery disease
Not Applicable
Completed
- Conditions
- Coronary artery disease patients with obstructive or central sleep apneaCirculatory System
- Registration Number
- ISRCTN50108373
- Lead Sponsor
- Canadian Institutes of Health Research
- Brief Summary
2016 results in https://pubmed.ncbi.nlm.nih.gov/27076578/ (added 15/10/2020) 2020 results in https://pubmed.ncbi.nlm.nih.gov/31957654/ (added 15/10/2020)
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- All
- Target Recruitment
- 34
Inclusion Criteria
Men and women 18-80 yrs of age with coronary artery disease (defined as a documented myocardial infarction, coronary bypass surgery or coronary angioplasty and/or stenting) and obstructive or central sleep apnea (AHI greater than 15 events/hr)
Exclusion Criteria
1. Angina
2. Use of diuretics
3. Adeno-tonsillar hypertrophy
4. Inability to walk due to orthopedic or musculoskeletal problems
5. Previously treated OSA
6. Patients exercising more than 150 minutes per week at moderate intensity
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Apnea hypopnea index, measured by polysomnogram at baseline and 4-weeks
- Secondary Outcome Measures
Name Time Method <br> 1. Leg fluid volume measured by bio-electrical impendence<br> 2. Overnight changes in leg fluid volume, thoracic fluid volume, neck circumference and neck fluid volume measured by bio-electrical impendence<br> 3. Upper-airway cross-sectional area measured by acoustic pharyngometry<br>