Effects of exercise on the heart, blood vessels and quality of life in individuals on two antihypertensive drugs

Not Applicable

Completed

Conditions: Hypertension
Circulatory System
Essential (primary) hypertension

Registration Number: ISRCTN81952488

Lead Sponsor: African Population Health and Research Centre (Kenya)

Brief Summary: Not available

Detailed Description: Not available

Recruitment & Eligibility

Status: Completed

Sex: All

Target Recruitment: 120

Inclusion Criteria

1. 18 years of age
2. Essential uncontrolled hypertension on 1 or 2 antihypertensive drugs
3. Resting BP from 140/90 to less than180/110mmHg

Exclusion Criteria

1. Currently pregnant or breast-feeding individuals
2. Cardiovascular diseases such as:
2.1. Unstable angina and arrhythmia
2.2. Class IV heart failure
2.3. Uncontrolled sustained tachyarrhythmias or bradyarrhythmias
2.4. Severe and symptomatic aortic or mitral stenosis
2.5. Hypertrophic obstructive cardiomyopathy
2.6. Active or suspected myocarditis or pericarditis
2.7. Thrombophlebitis
2.8. Recent significant systemic or pulmonary embolus
3. Syncopal disorder or orthostatic hypotension of defined by greater or equal to 20 mmHg decrease in standing systolic blood pressure (SBP) as compared to sitting SBP at screening or greater or equal to10 mmHg decrease in standing diastolic blood pressure (DBP) as compared to sitting DPB at screening
4. Participants with BP not less than180/110mmHg
5. Individuals with hyperglycaemia (diabetes)

Study & Design

Study Type: Interventional

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
1. Systolic blood pressure<br>2. Diastolic blood pressure<br>3. Number of antihypertensive drug<br>4. Quality of life

Secondary Outcome Measures

Name	Time	Method
1. Physical work capacity<br>2. Body mass index<br>3. Percent body fat<br>4. Waist circumference<br>5. Total cholesterol<br>6. Low-Density Lipoprotein (LDL) cholesterol<br>7. High-Density Lipoprotein (HDL) cholesterol<br>8. Triglyceride