Cross Correlation of Pain Hypersensitivity and Clinical Features and Electromyography in Low Back Pain Patients

Completed

• Conditions: Low Back Pain

• Registration Number: NCT01979315
• Lead Sponsor: University of Belgrade

Brief Summary

Diagnostic and prognostic value of pain hypersensitivity in low back pain (LBP) is not fully understood.Increased pain sensitivity in the primary area of pain (local pain) is considered a sign of predominantly peripheral pain sensitization,value of pain hypersensitivity in low back pain (LBP)is not fully understood whereas pain sensitivity in distal and remote areas is considered to present a more central phenomenon. It is suggested that pat ents with enhanced pain sensitivity report high level of disability. Despite fact that pain and disability are associated in chronic LBP the exact mechanisms of sensitivity contribution in LBP disability is unknown. It has also been suggested that muscle function changes may be driven by pain. The possible role and contribution of trunk muscles function to pain and disability phenomena remain unknown.

This study was aimed to estimate prevalence and possible correlation among pain hypersensitivity and functional and electromyography parameters of trunk muscles in patients reporting early phase of chronic LBP.

Detailed Description

Not available

Study Timeline

• Study First Submitted: 2013-10-25
• Study First Submitted QC: 2013-10-31
• Study First Posted: 2013-11-08
• Study Start: 2015-12
• Primary Completion: 2021-01
• Study Completion: 2021-05
• Status Verified: 2021-11
• Last Update Submitted: 2021-11-12
• Last Update Posted: 2021-11-16

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 60

Inclusion Criteria

• Low back pain for at least 12 weeks
• Magnetic resonance imaging (MRI) confirmation of prolapsed intervertebral disc (PID)
• No meeting excluding criteria.

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Exclusion Criteria

• No response to initial contact
• Red flag symptoms
• Diabetes mellitus,
• Neurological problems and
• Cancer
• Pregnant patients
• Patients treated chirurgically for the same problem or treated with oral corticosteroids and steroid injections for any reason in the previous month.

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Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Pain hypersensitivity parameters: pain threshold and pressure pain tolerance threshold will be measured by pressure algometer pressure was applied using a probe with an area of 1 cm2 and intensity to a maximum of 1,000 kPa at a rate of 30 kPa/s.	up to 3 months	pain detection threshold and pressure pain tolerance threshold (PPTT) )will be measured at the site of maximal pain and of more distant nonpainful point at the back, and the ipsilateral great toe 3 times and average value will be taken for statistics analyses

Trial Locations

Locations (1)

Clinic for rehabilitation dr Miroslav Zotovic Faculty of Medicine University of Belgrade; 🇷🇸 Belgrade, Serbia