Frequency of Sacroiliitis in Inflammatory Bowel Disease Patients Using MRI
试验速览
- 阶段
- 不适用
- 状态
- 尚未招募
- 入组人数
- 50
- 主要终点
- Primary (main)
研究概览
简要总结
- to determine the overall frequency of Inflammatory sacroiliitis among patients with Inflammatory bowel disease using magnetic resonance imaging
- identify the association of sacroliitis in IBD patients clinical and laboratory markers
详细描述
INFLAMMATORY BOWEL DISEASE (IBD) is a disorder in which an inappropriate response to an unknown antigen, combined with genetic and environmental factors, result in inflammation of the small bowel and colon . The two main forms of IBD are Crohn's disease (CD) and ulcerative colitis (UC) which are both associated with spondyloarthropathy (SpA), an inflammatory arthritis characterized by sacroiliitis and inflammatory back pain .
Articular manifestations of inflammatory bowel disease(IBD), comprising Crohn's disease (CD) and ulcerative colitis (UC), were first described in 1930 and have been considered as spondylarthropathies since 1978. They include peripheral arthritis and inflammatory axial involvement.
Extra-intestinal musculoskeletal manifestations associated with Inflammatory bowel disease, can be divided into axial and peripheral arthropathy, which can be a cause of significant morbidity that can adversely affect the quality of life in these patients. Peripheral arthropathy represent the most frequent (40%) extra-intestinal manifestation in IBD. These manifestations occur more frequently in patients with Crohn's disease.
Sacroiliitis (SI) is considered one of the common axial arthropathies with an estimated prevalence of around 10% of Crohn's patients.
It is crucial to differentiate inflammatory back pain due to axial SpA from other causes of chronic low back pain as they have different treatments and prognosis.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Only
- 时间视角
- Cross Sectional
入排标准
- 年龄范围
- 18 Years 至 65 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •subjects between 18 and 65 years.
- •subjects met clinical, pathological or radiological criteria of IBD.
排除标准
- •Patients who refuse enter the study
- •Patients who not diagnosed as IBD
- •other inflammatory arthritis (e.g. rheumatoid arthritis, systemic lupus erythematosus, psoriatic or reactive arthritis)
- •co-existent autoimmune diseases (e.g. celiac disease, Behcets disease)
- •malignancy less than 5 years in remission .
- •having a contraindication to MRI.
结局指标
主要结局
Primary (main)
时间窗: through study completion, an average of 1 year
Incidence of sacroliitis in inflammatory bowel disease patients using MRI with Inflammatory bowel disease using magnetic resonance imaging.
次要结局
- Secondary(through study completion, an average of 1 year)
研究者
Magy Wageeh Abdelmalak
Director
Assiut University