Effects of Resistance and Endurance Training on Synthesis of Individual Muscle Proteins in Young and Older Adults

Not Applicable

Completed

• Conditions: Sarcopenia

• Registration Number: NCT01489930
• Lead Sponsor: Mayo Clinic

Brief Summary

Loss of skeletal muscle strength and skeletal muscle mass occurs with of aging. This are-related decline in skeletal muscle mass and skeletal muscle strength is a major underlying factor contributing to many of the metabolic disorders and frailty of the investigators rapidly expanding aging population. Endurance (aerobic) and resistance exercise training programs have been shown to effectively reverse the age-related decline in metabolic and contractile muscle functions. The investigators will measure synthesis rates of individual muscle proteins in 36 each of young (18-30 yrs) and 36 older (\> 65 yrs) people to determine their response to 8 weeks each of endurance, resistance, combined endurance and resistance training, or placebo exercise training.

Hypotheses.

1. to measure fractional synthesis rates of multiple muscle proteins and identify those that are enhanced by an endurance exercise program

2. to determine whether changes in protein synthesis in response to endurance exercise programs are dependent on age

3. to measure fractional muscle synthesis rates of multiple muscle proteins and to identify those that are enhanced by a resistance exercise program

4. to determine whether changes in protein synthesis in response to resistance exercise programs are dependent on age

Detailed Description

Not available

Study Timeline

• Study Start: 2008-05
• Primary Completion: 2011-02
• Study Completion: 2011-02
• Study First Submitted: 2011-11-18
• Status Verified: 2011-12
• Study First Submitted QC: 2011-12-09
• Last Update Submitted: 2011-12-09
• Study First Posted: 2011-12-12
• Last Update Posted: 2011-12-12

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 67

Inclusion Criteria

• Healthy
• 18 to 30 or >65 years
• Males and Females

Exclusion Criteria

• Regular Exercise Program
• Smoking
• Cardiometabolic Disease (diabetes, cardiovascular disease, thyroid disorders)
• Drugs known to impair metabolic function (beta blockers, steroids)
• Allergies to lidocaine
• Physical disability that precludes exercise

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Primary Outcome Measures

Name	Time	Method
Skeletal Muscle Protein Synthesis	Measured at week 0 (baseline) and week 8	The investigators will determine the change from baseline in skeletal muscle protein synthesis. Measurments will be performed at baseline and following 8 weeks of exercise training.

Secondary Outcome Measures

Name	Time	Method
Mitochondrial Function	Measured at week 0 (baseline) and week 8	The investigators will determine the change from baseline in mitochondrial function. Measurments will be performed at baseline and following 8 weeks of exercise training.

Trial Locations

Locations (1)

Mayo Clinic; 🇺🇸 Rochester, Minnesota, United States