Optimal Flow Rate During Cardiopulmonary Bypass
- Conditions
- Tissue Perfusion
- Interventions
- Procedure: Flow rate
- Registration Number
- NCT01105078
- Lead Sponsor
- Johann Wolfgang Goethe University Hospital
- Brief Summary
Regardless of the development of cardiac surgery techniques and technologies, the question of an optimal extracorporeal circulation is still unanswered. There are globally accepted standards of perfusion, however, keep many of these procedures was not evidence-based review.
Generally accepted are flow rates during cardiopulmonary bypasses of 2.5 L/min/m2. This target was derived from the physiological conditions, but they are not the result of an adapted adjustment to the fundamentally non-physiological processes during extracorporeal circulation. Among other things, an increased metabolic demand during re-perfusion is not taken into account.
An increasing and optimizing of the standard flow rate of 0.5 L/min/m2 should be the aim of this investigation. Under optimal perfusion, the investigators are maintaining the microcirculation and organ protection in receipt of endothelial function and oxygen transport.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- UNKNOWN
- Sex
- All
- Target Recruitment
- 60
- Extracorporeal circulation
- Age > 18
- Written consent
- Emergency cases
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Arm && Interventions
Group Intervention Description Flow rate Flow rate Comparison between a flow rate of 2.5/l/min/m2 versus 3.0/l/min/m2
- Primary Outcome Measures
Name Time Method Microcirulation intraooperative measurement with O2C
- Secondary Outcome Measures
Name Time Method
Trial Locations
- Locations (1)
Johann Wolfgang Goethe University Hospital
🇩🇪Frankfurt am Main, Germany