NCT02852759已完成不适用
A Cold Physical Treatment to Manage Insulin Resistance
适应症
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 33
- 试验地点
- 1
- 主要终点
- Change of Glucose Tolerance measured by OGTT
研究概览
简要总结
Insulin resistant volunteers will choose to undergo an 8-week cold treatment, 2 hours per day, to selective regions of the body enriched with brown fat including neck, supraclavicular and interscapular regions) in combination with electroacupuncture (EA). Their insulin sensitivity and glucose and lipid homeostasis will be measured. The brown fat activation will be assessed by positron emission tomography and computed tomography (PET/CT)-scans and/or serum marker measurements.
研究设计
- 研究类型
- Interventional
- 分配方式
- Non Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 60 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •BMI: 20-30
- •Insulin resistant
排除标准
- •uncontrolled hypertension
- •insulin dependent diabetics
- •heart diseases
- •hyperthyroidism
- •secondary obesity
- •surgical operation within treatment or planned in two months
- •pregnancy
- •liver or kidney failure
结局指标
主要结局
Change of Glucose Tolerance measured by OGTT
时间窗: 0, 8 week, 2 hours for each measurement
glucose tolerance at 8 weeks will be compared to 0 week
次要结局
- Change of 2-deoxy-2-[fluorine-18]fluoro- D-glucose (FDG) uptake by PET/CT-scans(0 and 8 week, 2 hours for each measurement)
- Change of serum insulin levels(0, 8 week)
- Change of Body weight(0, 8 week)
- Change of glucose infusion rate by hyperinsulinemic euglycemic clamp(0 and 8 week, 5 hours for each measurement)
研究者
研究点 (1)
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