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临床试验/NCT00486551
NCT00486551已完成不适用

Anger Control Training for Youth With Tourette Syndrome

Yale University2 个研究点 分布在 1 个国家目标入组 26 人开始时间: 2001年8月最近更新:
适应症

试验速览

阶段
不适用
状态
已完成
入组人数
26
试验地点
2
主要终点
Parent rated disruptive behavior

研究概览

简要总结

This is a clinical study of a cognitive-behavioral therapy known as anger control training in adolescents with Tourette Syndrome and explosive, disruptive behavior. ACT is compared to treatment as usual (TAU) in a randomized clinical trial.

详细描述

This is a randomized controlled study of a cognitive-behavioral, anger control training (ACT) in adolescents with Tourette Syndrome (TS) complicated by disruptive behavior. Disruptive behaviors in TS may take numerous forms including noncompliance, anger outbursts, and physical aggression. Anger outbursts in TS have been described as rage attacks or rage storms due to their high intensity and unpredictability in response to minimal provocation. Whether these behaviors are part of TS, related to comorbid conditions, or due to the burden of chronic illness is not clear. Nevertheless, these disruptive behaviors can result in significant functional impairment and often require clinical attention. The purpose of the ACT intervention is to improve the explosive and noncompliant behavior in adolescents with TS by enhancing affect regulation and social problem-solving skills. The treatment is based on anger control training which has been empirically supported for reducing aggressive behaviors and improving social functioning in aggressive youths. The primary outcome measures include the parent-rated Oppositional Defiant Scale and the Clinicians Global Improvement Score assessed by a clinician blind to treatment assignment.

研究设计

研究类型
Interventional
分配方式
Randomized
干预模型
Parallel
主要目的
Treatment
盲法
Single

入排标准

年龄范围
11 Years 至 16 Years(Child)
性别
All
接受健康志愿者

入选标准

  • Boys and girls, 11 to 16 years of age.
  • Diagnosis of Tourette syndrome (TS) or chronic tic disorder (CTD).
  • Significant level of disruptive behavior

排除标准

  • Current diagnosis of Severe Major Depression, Bipolar Disorder, Pervasive Developmental Disorder, or Psychotic Disorder.
  • Significant medical condition such as heart disease, hypertension, liver or renal failure, pulmonary disease, seizure disorder that may require more pressing treatment.
  • Initiation or discontinuation of a psychotropic medication treatment within six weeks of enrollment in the study

结局指标

主要结局

Parent rated disruptive behavior

时间窗: three months

CGI-I assigned by clinician unaware of treatment assignment

时间窗: three months

次要结局

未报告次要终点

研究者

申办方类型
Other

研究点 (2)

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