The Effect of Concentrated Pomegranate Juice Consumption on Lipid Profile and Inflammatory Factors in Patients With Type 2 Diabetes

Not Applicable

• Conditions: Type 2 Diabetes
• Interventions: Other: 50 gr concentrated pomegranate juice

• Registration Number: NCT02024516
• Lead Sponsor: Ahvaz Jundishapur University of Medical Sciences

Brief Summary

The aim of this study is to examine the effects of concentrated pomegranate juice on serum lipid profile and some inflammatory factors in patients with type 2 diabetes. Forty patients aged between 25-60 years old from both sexes are recruited. Patients consume 50gr/day concentrated pomegranate juice for 4 weeks. Anthropometric and blood pressure measurements, 3-days food-record questionnaire ,physical activity and fasting blood samples were collected at the beginning and at the end of the study. Fasting blood sugar, lipid profile, TNF- a, IL-6,hs -CRP and adiponectin levels are measured. LDL are calculated by formula. The participants are asked not to change their regular diet, medicine and activity during the study.

Detailed Description

Not available

Study Timeline

• Study Start: 2013-01
• Status Verified: 2013-12
• Primary Completion: 2013-12
• Study First Submitted: 2013-12-14
• Study First Submitted QC: 2013-12-30
• Last Update Submitted: 2013-12-30
• Study First Posted: 2013-12-31
• Last Update Posted: 2013-12-31

Recruitment & Eligibility

• Status: UNKNOWN
• Sex: All
• Target Recruitment: Not specified

Inclusion Criteria

• male or female 25 to 60 years old
• having type 2 diabetes for at least 6 month

Exclusion Criteria

• pregnancy
• lactation
• cardiac disease
• hepatic disease
• respiratory disease
• chronic renal diseases
• acute or chronic inflammation
• retinopathy
• intake of antioxidant supplement
• insulin therapy
• sensitivity to concentrated pomegranate juice
• change oral drug for controlling blood glucose

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: SINGLE_GROUP

Arm && Interventions

Group	Intervention	Description
50 gr concentrated pomegranate juice	50 gr concentrated pomegranate juice	-

Primary Outcome Measures

Name	Time	Method
adiponectin change	Baseline and after 4 weeks
Triglyceride change	Baseline and after 4 weeks
HDL- Cholesterol change	Baseline and after 4 weeks
Total Cholesterol change	Baseline and after 4 weeks
hsCRP change	Baseline and after 4 weeks
TNF- α change	Baseline and after 4 weeks
IL-6 change	Baseline and after 4 weeks
LDL- Cholesterol change	Baseline and after 4 weeks

Secondary Outcome Measures

Name	Time	Method
Fasting Blood Sugar change	baseline and after 4 weeks
Body Mass Index change	baseline and after 4 weeks
Blood Pressure change	Baseline and after 4 weeks

Trial Locations

Locations (1)

Ahvaz Jundishapoor University of Medical Sciences; 🇮🇷 Ahvaz, Khoozestan, Iran, Islamic Republic of