Effects of Total Knee Replacement on Early Postoperative Cognitive Function in Elderly Patients
Completed
- Conditions
- Perioperative Complications
- Registration Number
- NCT02387541
- Lead Sponsor
- General Hospital of Ningxia Medical University
- Brief Summary
To investigate the effects of total knee replacement is harmful to Postoperative cognitive dysfunction
- Detailed Description
Postoperative cognitive dysfunction (POCD) is reported to occur after major surgery in elderly patients. They may especially experience problems in the weeks and months after surgery. Recent studies vary greatly in methods of evaluation and diagnosis of POCD, and the pathogenic mechanisms are still unclear. The investigators evaluated a large uniform cohort of elderly patients in a standardized approach after total knee replacement.
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 100
Inclusion Criteria
- aged ≥65 years;
- ASA I or Ⅱ;
- total knee replacement
Exclusion Criteria
- Mini Mental State Examination [MMSE] score too low.
- Parkinson or other neurological disease causing functional impairment.
- Patients with a history of alcohol abuse (≥35 U per week) or daily use of anxiolytics were also excluded, as well as those with severe hearing or visual impairment.
Study & Design
- Study Type
- OBSERVATIONAL
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Effects of operation on early postoperative cognitive function in elderly patients up to 7days postoperatively
- Secondary Outcome Measures
Name Time Method Postoperative cognitive dysfunction (POCD) was defined by Mini-Mental State Examination (MMSE) score up to 7days postoperatively