Effects of Total Knee Replacement on Early Postoperative Cognitive Function in Elderly Patients

General Hospital of Ningxia Medical University0 sites100 target enrollmentMarch 2012

ConditionsPerioperative Complications

Overview

Phase: Not Applicable
Intervention: Not specified
Conditions: Perioperative Complications
Sponsor: General Hospital of Ningxia Medical University
Enrollment: 100
Primary Endpoint: Effects of operation on early postoperative cognitive function in elderly patients
Status: Completed
Last Updated: 10 years ago

Overview Investigators Eligibility Criteria Outcomes Similar Trials

Overview

Brief Summary

To investigate the effects of total knee replacement is harmful to Postoperative cognitive dysfunction

Detailed Description

Postoperative cognitive dysfunction (POCD) is reported to occur after major surgery in elderly patients. They may especially experience problems in the weeks and months after surgery. Recent studies vary greatly in methods of evaluation and diagnosis of POCD, and the pathogenic mechanisms are still unclear. The investigators evaluated a large uniform cohort of elderly patients in a standardized approach after total knee replacement.

Registry

clinicaltrials.gov

Start Date

March 2012

End Date

January 2014

Last Updated

10 years ago

Study Type

Observational

Sex

All

Investigators

Sponsor

General Hospital of Ningxia Medical University

Responsible Party

Sponsor

Eligibility Criteria

Inclusion Criteria

•aged ≥65 years;
•ASA I or Ⅱ;
•total knee replacement

Exclusion Criteria

•Mini Mental State Examination \[MMSE\] score too low.
•Parkinson or other neurological disease causing functional impairment.
•Patients with a history of alcohol abuse (≥35 U per week) or daily use of anxiolytics were also excluded, as well as those with severe hearing or visual impairment.