NCT02387541已完成不适用
Effects of Total Knee Replacement on Early Postoperative Cognitive Function in Elderly Patients
General Hospital of Ningxia Medical University0 个研究点目标入组 100 人开始时间: 2012年3月最近更新:
适应症
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 100
- 主要终点
- Effects of operation on early postoperative cognitive function in elderly patients
研究概览
简要总结
To investigate the effects of total knee replacement is harmful to Postoperative cognitive dysfunction
详细描述
Postoperative cognitive dysfunction (POCD) is reported to occur after major surgery in elderly patients. They may especially experience problems in the weeks and months after surgery. Recent studies vary greatly in methods of evaluation and diagnosis of POCD, and the pathogenic mechanisms are still unclear. The investigators evaluated a large uniform cohort of elderly patients in a standardized approach after total knee replacement.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Control
- 时间视角
- Prospective
入排标准
- 年龄范围
- 65 Years 至 —（Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •aged ≥65 years;
- •ASA I or Ⅱ;
- •total knee replacement
排除标准
- •Mini Mental State Examination [MMSE] score too low.
- •Parkinson or other neurological disease causing functional impairment.
- •Patients with a history of alcohol abuse (≥35 U per week) or daily use of anxiolytics were also excluded, as well as those with severe hearing or visual impairment.
结局指标
主要结局
Effects of operation on early postoperative cognitive function in elderly patients
时间窗: up to 7days postoperatively
次要结局
- Postoperative cognitive dysfunction (POCD) was defined by Mini-Mental State Examination (MMSE) score(up to 7days postoperatively)
研究者
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