Cognition Following Computer Assisted Total Knee Arthroplasty

Completed

• Conditions: Cognition; Embolism, Fat

• Registration Number: NCT00830986
• Lead Sponsor: Rothman Institute Orthopaedics

Brief Summary

A significant number of patients experience postoperative cognitive changes following total joint arthroplasty. Among other causes, the mental status change may be the result of fat and bone marrow debris embolization. We hypothesized that the use of computer assisted total knee arthroplasty, which does not utilize intramedullary alignment rods, would produce less fat and bone marrow debris embolization and, hence, fewer mental status changes.

Detailed Description

Inclusion criteria

* Primary, cemented knee arthroplasty

* Unilateral or bilateral TKA

Exclusion criteria

* Patient is unable to speak English

* Unable to read and write

* Patient with history of psychiatric disorders (Depression, Schizophrenia, anxiety, bipolar dis.)

* Patients with history of IV drug abuse

* Previous history of dementia

* Patients on mental status changing medications

Study Timeline

• Study Start: 2005-07
• Primary Completion: 2006-03
• Study Completion: 2006-03
• Status Verified: 2009-01
• Study First Submitted: 2009-01-26
• Study First Submitted QC: 2009-01-26
• Study First Posted: 2009-01-28
• Last Update Submitted: 2009-04-14
• Last Update Posted: 2009-04-16

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 100

Inclusion Criteria

• Primary, cemented knee arthroplasty
• Unilateral or bilateral TKA

Exclusion Criteria

• Patient is unable to speak English
• Unable to read and write
• Patient with history of psychiatric disorders (Depression, Schizophrenia, anxiety, bipolar dis.)
• Patients with history of IV drug abuse
• Previous history of dementia
• Patients on mental status changing medications

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Folstein Mini Mental State Examination (MMSE)	6 Months Post-Operative