Effectiveness of Dexamethasone Injection on Postoperative Pain After Impacted Third Molar Surgery Assessed Using Visual Analog Scale
试验速览
- 阶段
- 不适用
- 状态
- 进行中（未招募）
- 发起方
- 入组人数
- 70
- 试验地点
- 1
- 主要终点
- Postoperative pain intensity
研究概览
简要总结
This randomized clinical trial aims to evaluate the effectiveness of dexamethasone injection in reducing postoperative pain after surgical removal of impacted mandibular third molars. Patients are divided into two groups: one receiving standard local anesthesia, and the other receiving an additional dexamethasone injection postoperatively. Pain levels are assessed using the Visual Analogue Scale (VAS) at 24, 48, and 72 hours after surgery. The study is conducted at 28 Military Dental Centre, Lahore.
详细描述
Impacted mandibular third molar surgery is commonly associated with postoperative pain, which can affect patient comfort and recovery. Corticosteroids such as dexamethasone have anti-inflammatory properties and may reduce postoperative pain and swelling.
This randomized clinical trial is designed to compare postoperative pain levels in patients undergoing third molar surgery with and without the administration of dexamethasone. Patients are randomly allocated into two groups. Group 1 receives standard inferior alveolar nerve block using 2% lignocaine with epinephrine. Group 2 receives an additional 1 ml (8 mg) dexamethasone injection in the buccal vestibule after completion of surgery.
Pain is assessed using the Visual Analogue Scale (VAS) at 24, 48, and 72 hours postoperatively. All patients are prescribed the same postoperative analgesic regimen. The primary outcome is the difference in mean pain scores between the two groups. Data analysis is performed using SPSS, and statistical significance is set at p < 0.05.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- None
盲法说明
This is an open-label study. Participants and investigators are aware of the assigned interventions, as one group receives dexamethasone while the control group receives standard postoperative care without dexamethasone.
入排标准
- 年龄范围
- 20 Years 至 40 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Patients aged 20 to 40 years
- •Patients with at least one impacted mandibular third molar (Class A or B, Class I or II) including mesioangular, horizontal, vertical, or distoangular impactions according to Pell and Gregory classification confirmed by panoramic radiograph
- •Patients with no systemic disease (e.g., diabetes mellitus, hypertension, ischemic heart disease)
- •Patients of either gender
排除标准
- •Patients who have used analgesics or related drugs within 15 days prior to surgery
- •Pregnant patients
- •Patients with known allergy to corticosteroids
- •Patients with tooth associated with cyst, tumor, or trauma
研究组 & 干预措施
Control Group
Participants will receive standard postoperative care without dexamethasone following surgical removal of impacted mandibular third molars.
Dexamethasone Group
Dexamethasone 8 mg (1 ml) was administered via buccal vestibular injection immediately after surgical removal of impacted mandibular third molars.
干预措施: Dexamethasone (Drug)
结局指标
主要结局
Postoperative pain intensity
时间窗: 24 hours, 48 hours, and 72 hours postoperatively
Postoperative pain will be assessed using a 10-point Visual Analog Scale (VAS), where 0 indicates no pain and 10 indicates worst possible pain, following surgical removal of impacted mandibular third molars.
次要结局
未报告次要终点
研究者
Maryam Umar
Resident, Oral and maxillofacial surgery
28 Military Dental Centre Lahore